Lecture 6 - Synaptic Transmission + Neuromuscular Junction Flashcards
What do the -caine drugs do? (procaine, lidocaine, novocaine, cocaine)
Reversibly bind and block voltage gated Na+ channels prohibiting AP’s from occurring thus no pain
What does TTX (tetrodotoxin) do?
IRREVERSIBLY binds with and blocks voltage gated Na+ channels
Whats one animal that has TTX?
Puffer fish
What is the most common excitatory synapse in the nervous system?
Glutamatergic synapse
What is the NT used for the glutamatergic synapse?
glutamate
What is the most common inhibitory synapse in the nervous system?
GABAergic synapse
What NT is used for the GABAergic synapse?
GABA
How is the glutamatergic synapse excitatory?
Glutamate opens ion channels allowing NA to enter the neuron, making it more positive
Hop is the GABAergic synapse inhibitory?
GABA opens ion channels allowing Cl- into the neuron making it more negative
Do EPSP’s bring you closer or further to threshold?
closer
Do IPSP’s bring you closer or further to threshold?
Further
What is a neuromuscular junction?
Synapse between motor neurons and muscle fibres
Where do alpha motor neurons synapse?
Onto muscle fibres
Where do the axons of alpha motor neurons connect?
To a group of muscle fibres
Why do alpha motor neurons innervate multiple muscle fibres?
to have even force distribution for even force production
