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Histology Exam 1 (Brendan) > Lecture 5 Organelles > Flashcards

Lecture 5 Organelles Flashcards

1
Q

Mitochondrion have an outer bonding membrane and inner membrane that invaginate to form ____

A

cristae

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2
Q

Matrix granules of mitochondrion increase in number when ____ increase in cytoplasm

A

cations

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3
Q

Matrix of mitochondria contains all the enzymes of the TCA cycle other than _____

A

succinate dehyrdogenase

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4
Q

Elementary particles of mitochondrion contain_____

A

ATP synthase

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5
Q

Mitochondrial have their own genetic apparatus composed of ____ DNA, mRNA, tRNA, and rRNA

A

circular

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6
Q

____ are integral outer membrane proteins that form channels to allow small molecoules to freely pass from cytoplasm to intermembrane space

A

Porins

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7
Q

Mitochondria linked diseases mainly affect tissues/organs with high _____ requirement

A

energy

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8
Q

_____ are among the first organelles to show that something is wrong in the cell.

A

Mitochondria

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9
Q

rER stains ____ with H and E stains

A

basophilic/purple

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10
Q

____ is the site of noncytosolic protein synthesis (ie for secretory, plasma-membrane, and lysosomal proteins)

A

rER

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11
Q

the interior ER region is called the lumen or ____

A

cisterna

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12
Q

rER is abundant in cells synthesizing ____

A

secretory proteins

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13
Q

phospholipids for new membranes are produced in the ____ half of the ER

A

Cytosolic

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14
Q

Many proteins have N-linked ________ attached in the ER and are further modified in the ____

A

oligosaccharides

golgi

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15
Q

Smooth ER lack _____

A

ribosomes

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16
Q

Smooth ER is found abundantly in ______ synthesizing cells and in cells involved in synthesis of triglycerides

A

steroid

examples=leydig cells

17
Q

_____ is involved in drug detoxification (contains cytochrome P450

A

Smooth ER

18
Q

The ____ consists of several sticks of disk shaped saccules.

A

Golgi

19
Q

_____ staining does not stain golgi

A

H and E

20
Q

____ modifies N-oligosaccharides, distrubutes non-cytosolic proteins, assembles proteoglycans, and adds mannose-6-phosphate to proteins targeted for lysosomes

A

Golgi

21
Q

Golgi consists of 2 faces: _____ face, which is located at the side of the stack facing the rER and is associated with small transfer vesicles and the _____ face, which comprises the maturing cisternae and secretory granules

A

cis,

trans

22
Q

Peroxisomes are organelles found primarily in the _____, as well as skeletal muscle and kidney

A

liver

23
Q

Peroxisomes can be identified by a cytochemical reaction for ____ and a nucleoid

A

catalase

24
Q

_____ contain oxidative enzymes involved beta-oxidation of long chain fatty acids and the detoxification of substances such as ethanol

A

Peroxisomes

25
Q

____ breakdown hydrogen peroxide and participates in cholesterol synthesis, containing the critical HMG-CoA reductase

A

peroxisomes

26
Q

_____ syndrome is a peroxisome related disease that causes fatty acids to accumulate in tissue

A

Zellweger

27
Q

Pigments, lipids, crystals, and granules are all examples of _____

A

inclusions

28
Q

______ and ______ are the only organelles not visible with a light microscope

A

Ribosomes

plasma membrane

29
Q

______ is a mitochondrial-linked disease that causes paralysis of eye muscles

A

CPEO

30
Q

______ is a mitochondrial linked disease involving abnormal movements due to muscular rigidity. It is frequently accompanied by degeneration of the basal ganglia

A

Dystonia

31
Q

____ is a mitochondrial-linked disease where CPEO is combined with disorders such as renal deterioration, heart disease, hearing loss, and diabetes

A

KSS

32
Q

____ syndrome is a mitochondrial linked disease characterized by progressive loss of motor and verbal skills and degeneration of the basal ganglia.

A

Leigh’s

33
Q

LHON is a ______-linked disease characterized by permanent of temporary blindness due to damage to the optic nerve

A

mitochonria

34
Q

_ ER is studded with ribosomes while _ ER does not contain any

A

Rough, smooth

35
Q

____ ER in hepatocytes is increased by drugs such as phenobarbital

A

smooth

36
Q

The ____ golgi network lies apart from the last cisterna is separated from the golgi stack

A

trans

Histology Exam 1 (Brendan) (10 decks)

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