Lecture 5 Organelles

Question 1

Mitochondrion have an outer bonding membrane and inner membrane that invaginate to form ____

Answer 1

cristae

Question 2

Matrix granules of mitochondrion increase in number when ____ increase in cytoplasm

Answer 2

cations

Question 3

Matrix of mitochondria contains all the enzymes of the TCA cycle other than _____

Answer 3

succinate dehyrdogenase

Question 4

Elementary particles of mitochondrion contain_____

Answer 4

ATP synthase

Question 5

Mitochondrial have their own genetic apparatus composed of ____ DNA, mRNA, tRNA, and rRNA

Answer 5

circular

Question 6

____ are integral outer membrane proteins that form channels to allow small molecoules to freely pass from cytoplasm to intermembrane space

Answer 6

Porins

Question 7

Mitochondria linked diseases mainly affect tissues/organs with high _____ requirement

Answer 7

energy

Question 8

_____ are among the first organelles to show that something is wrong in the cell.

Answer 8

Mitochondria

Question 9

rER stains ____ with H and E stains

Answer 9

basophilic/purple

Question 10

____ is the site of noncytosolic protein synthesis (ie for secretory, plasma-membrane, and lysosomal proteins)

Answer 10

rER

Question 11

the interior ER region is called the lumen or ____

Answer 11

cisterna

Question 12

rER is abundant in cells synthesizing ____

Answer 12

secretory proteins

Question 13

phospholipids for new membranes are produced in the ____ half of the ER

Answer 13

Cytosolic

Question 14

Many proteins have N-linked ________ attached in the ER and are further modified in the ____

Answer 14

oligosaccharides

golgi

Question 15

Smooth ER lack _____

Answer 15

ribosomes

Question 16

Smooth ER is found abundantly in ______ synthesizing cells and in cells involved in synthesis of triglycerides

Answer 16

steroid

examples=leydig cells

Question 17

_____ is involved in drug detoxification (contains cytochrome P450

Answer 17

Smooth ER

Question 18

The ____ consists of several sticks of disk shaped saccules.

Answer 18

Golgi

Question 19

_____ staining does not stain golgi

Answer 19

H and E

Question 20

____ modifies N-oligosaccharides, distrubutes non-cytosolic proteins, assembles proteoglycans, and adds mannose-6-phosphate to proteins targeted for lysosomes

Answer 20

Golgi

Question 21

Golgi consists of 2 faces: _____ face, which is located at the side of the stack facing the rER and is associated with small transfer vesicles and the _____ face, which comprises the maturing cisternae and secretory granules

Answer 21

cis,

trans

Question 22

Peroxisomes are organelles found primarily in the _____, as well as skeletal muscle and kidney

Answer 22

liver

Question 23

Peroxisomes can be identified by a cytochemical reaction for ____ and a nucleoid

Answer 23

catalase

Question 24

_____ contain oxidative enzymes involved beta-oxidation of long chain fatty acids and the detoxification of substances such as ethanol

Answer 24

Peroxisomes

Question 25

____ breakdown hydrogen peroxide and participates in cholesterol synthesis, containing the critical HMG-CoA reductase

Answer 25

peroxisomes

Question 26

_____ syndrome is a peroxisome related disease that causes fatty acids to accumulate in tissue

Answer 26

Zellweger

Question 27

Pigments, lipids, crystals, and granules are all examples of _____

Answer 27

inclusions

Question 28

______ and ______ are the only organelles not visible with a light microscope

Answer 28

Ribosomes | plasma membrane

Question 29

______ is a mitochondrial-linked disease that causes paralysis of eye muscles

Answer 29

CPEO

Question 30

______ is a mitochondrial linked disease involving abnormal movements due to muscular rigidity. It is frequently accompanied by degeneration of the basal ganglia

Answer 30

Dystonia

Question 31

____ is a mitochondrial-linked disease where CPEO is combined with disorders such as renal deterioration, heart disease, hearing loss, and diabetes

Answer 31

KSS

Question 32

____ syndrome is a mitochondrial linked disease characterized by progressive loss of motor and verbal skills and degeneration of the basal ganglia.

Answer 32

Leigh's

Question 33

LHON is a ______-linked disease characterized by permanent of temporary blindness due to damage to the optic nerve

Answer 33

mitochonria

Question 34

_ ER is studded with ribosomes while _ ER does not contain any

Answer 34

Rough, smooth

Question 35

____ ER in hepatocytes is increased by drugs such as phenobarbital

Answer 35

smooth

Question 36

The ____ golgi network lies apart from the last cisterna is separated from the golgi stack

Answer 36

trans