Lecture 5: Lymphatic System Flashcards
How do capillaries filter fluid from the blood?
- hydrostatic pressure from the heart
- osmotic pressure from ihgh conc. of proteins in blood
Edema stems from what?
build-up of lymph
What is associated with an increase in edema?
- reduced physical activity
- low blood pressure
- damage to valves in lymohatic vessels
- cutting through lymphatic vessels during surgery
What are the 2 regions of lymph nodes?
- sinuses containing macrophages & dendritic cells
- inner medula with plasma, T, & B cells
What are the functions of lymph nodes?
- monitor/ filter harmful particles from lymph
- major site of lymphocyte production
- lymphocytes attack bacteria, parasites, & viruses
What are the 2 lymphatic ducts?
- thoracic duct -> collects lymph from most of the body
- right lymphatic duct -> collects from right upper side
All blood cells form where?
bone marrow
What are thymocytes?
cells that travel from the bone marrow to thymus then mature into T cells
Where do thymocytes mature?
in the cortex
What are the 2 regions of the thymus?
outer cortex & inner medulla
What cells are in the outer cortex of the thymus?
- epithelial
- macrophages
- dendritic
What are MHC proteins?
specialized surface proteins used to present antigens
What is positive selection in the lymphatic system?
whether or not a thymocyte can bind to MHCs (no= apoptosis; yes= move on to medulla) (want yes)
What receptors help to distinguish T cells?
CD4 & CD8
What is negative selection in the lymphatic system?
whether cells can bind to antigens (want to be no)
