Lecture 2: Cardiovascular System Flashcards
Does blood leave vessels?
no
What are the 3 parts of the cardio system?
- heart -> provides force to pump blood
- blood vessels -> house & trabsport blood
- blood -> carries & trabsports materials
What makes 55% of blood volume?
matrix/plasma
What are the 2 functions of blood vessels?
- prvent leakege of materials
- provide selectively permeable barrier
What are the formed elements in blood?
- RBCs -> 95%; erythrocytes responsible for gas transport
- cellular fragments -> platelets responsible for clotting
- WBCs -> .1%; leukocytes responsible ofr immune response
Where do all formed elements come from?
bone marrow
Where is embryonic hematopoiesis found?
- yolk sac
- liver
- spleen
- bone marrow
- spongy bone
- medullary cavity
Where are formed elements found in adults?
- spongy bone of axial skeleton
- long bones
- lymph nodes
- bone marrow
What 2 organs retain hematopoietic ability but are inactive?
liver & spleen
Where do lymphoid stem cells differentiate?
- T cells & NK cells -> in lymphatic tissue & thymus
- B cells -> in bone marrow
What do myeloid stem cells produce?
- progenitor cells to respond to chemicals
- megakaryocytes -> thrombocytes/platelets
- erythrocyte -> RBCs
- myeloblast -> WBCs (basophils, neutrophil, eosinophil)
Where do erythrocytes originate?
kidneys then bone marrow
What do eerythrocytes release that trigger RBC production?
erythropoietin
What is anemia?
deficiency in RBCs or hemoglobin
What is the composition of hemoglobin?
- 4 globin subunits with heme group
- each heme has an iron factor & binds one O2
- amino acid in globin bind CO2