Lecture 4: Heart Structure & Function Flashcards
Where will pressure in cardio system be the highest?
when ventricles contract in aorta during systole
What are the 2 layers pericardium?
- parietal -> fibrous & attaches to diaphragm
- visceral -> fuses to surface of the heart
What is the space between the visceral & parietal pericardium called?
pericardial cavity -> filled with fluid to lubricate
Where does the heart lie?
in the pericardium
Which pericardium forms the outer epicardium?
visceral pericardium
What are the 3 layers of the heart?
- epicardium -> outer layer with blood vessels
- myocardium -> muscle layer in the middle
- endocardium -> thin epithelium & connective tissue on the inside
How is the heart formed?
- from mesoderm as 2 cardiogenic cords
- single heart tube formed by lumen
How does blood enter & exit the heart?
- enters posteriorly
- exits anteriorly
What is the sinus venosus?
accepts blood into the heart
Where does the blood go once into the heart?
- accepted into heart by sinus venosus
- sinoatrial valve to atrium
- atrioventricular valve to ventricle
- ventricles send blood into bulbus cordis
- exits bulbus & enters truncus arteriosus
The sinus venosus becomes what of the right atrium?
SA node
What are the changes in structures within the heart?
- atrium -> left & right atria
- ventricle -> left ventricle
- bulbus cordis -> right ventricle
- truncus -> ascending aorta & pulmonary trunk
How does deoxygenated blood enter the heart?
through vena cava - > right atrium -> tricuspid valve
How is the tricuspid valve held to the ventricular wall?
chordae tendineae
How is the tricuspid valve anchored?
by papillary muscles
How does oxygenated blod enter the left atrium?
enters via pulmonary veins from lungs
The left atrium has what cusps?
bicuspid/ mitral valve
Actin & myosin are organized into what?
sarcomeres
Cardiac muscle is composed of what cells?
uninucleate branched cells
Intercalated discs are composed of what 2 things?
- gap junctions -> allow Ca2+ to pass b/w cells for contractions
- desmosomes -> keep cells tight together
What is the heart chambers cycle?
- relaxation of empty ventricles
- opens mitral & tricuspid valves to pull blood in
- atria contract to force blood into ventricles
What occurs when the mitral & tricuspid valves are closed?
- ventricles contract
- aortic & pulmonary valves open & blood leaves
- atrial relaxation allows blood to fill
- negative pressure of pericardium
- all 4 chambers relax
What do the 1st & 2nd sound mean with a heartbeat?
- 1st sound -> mitral & tricuspid closing / ventricle contracts
- 2nd sound -> pulmonary & aortic closing / ventricle relaxation
What node acts as a pacemaker for the heart?
sinoatrial node
What occurs as electrical signals travel via intercalated discs?
- rhythmic contraction of chambers
- depolarization sends signals through cardiac conducting tarcts
How is the contraction of the atria triggered?
- Bachman’s bundle sends signal to left atrium
- tracts within right atrium trigger contraction
What happens when non-conductive tissue blocks the way?
signals cannot pass to ventricles
The electrical signal in the heart takes 50 milliseconds to reach where?
AV node
The AV bundle is also known as what?
Bundle of His
What is the path of electrical activity in the heart?
SA node -> right & left (Bachman’s bundle ) atrium -> AV node -> AV bundle/Bundle of His -> right & left ventricle
What does the depolarization of cardiac cells rely on?
Na+ & Ca2+
How do cardiac cells become depolarized?
- resting membrane potential is unstable; only -60mV
- K+ channels open at +5mV
What nerves regulate the SA node?
vagus & sympathetic nerves
What glands regulate the SA node?
thyroid (T3 & t4) & adrenal (norepeinephrine & epinephrine)
What happens during the plateau of contractile cells?
- as Na+ close, Ca2+ & K+ channels open
- Ca2+ moves in slowly while K+ moves out
- creates refractory period
What does the PR interval represent?
- depolarization of SA node
- how long it takes for impulse to reach AV node
What does the QRS interval represent?
depolarization of ventricle
What does the T wave represent?
repolarization of ventricle
What does the P wave represent?
depolarization of atria
What does the QRS complex represent?
depolarization of ventricles