Lecture 44: T Cells Flashcards
Within the ER, peptides along with other things are loaded on to the MHC class __ molecule.
- I (one)
How are MHC-II molecules loaded with peptides?
- Phagocytosis
- Phagolysosome formed
- Class II loads peptide on (in phagolysosome)
- Specificity
DC can present viral antigens via MHC-__? It’s a rule breaker in the regard that a virus is able to take both class I and class II pathways.
- II
Dendritic cells travelling through lymphatic vessels it will eventually arrive in a lymph node, and meet __ cells. Of all cells, DCs make up _%.
- T
- 1
DCs nestle in the __ cell areas and if you zoom in you can see that they’re right amongst them.
- T
CD4 T Cell is able to provide help usually in the form of _______.
- Cytokines
T Cells are _______ that arise in the ___ ______ and fully develop in the _____. T Cells express T Cell Receptor with co-receptors (either ___ or CD8)
- Lymphocytes
- Bone
- Thymus (university)
- CD4
The Thymus is used to weed out…
- Weak / Useless / Dangerous T Cells
- Screens all T Cells
- Only useful T Cells are allowed to emerge
Gene rearrangement occurs so that T Cells express unique ______. There’s a large number of them, big library, don’t know which may save our lives but know that some will. Different T Cells operate during different infections.
- Receptors
CD4 = ? CD8 = ?
- Recognises MHC-II peptide
- MHC-I
CD4 T Helper Cell:
- Helps CD8-T become cytotoxic
- Cytokine (eg IL-1) production
CD8 T Cell recognises…
- MHC-I peptide
- Develops into Cytotoxic T Cell
What do Cytotoxic Cells do?
- Releases enzymes that virally infected cells receive and “kill themselves”
HIV attacks what receptors?
- CD4
Memory T Cells are much quicker than ____ T Cells because they have ____ activation, and are there in _____ numbers.
- Naive
- Lower
- Greater
