Lecture 24: Synaptic Networks Flashcards
Different types of neurotransmitters:
- Acetylcholine (ACh)
- Glutamate (EPSP)
- GABA (IPSP)
- Norepinephrine / Noradrenaline
- Dopamine
- Serotonin
Methamphetamine increases levels ofβ¦.
It also blocks β¦. It lingers in the synaptic cleft. Also acting in the ____ _____, making it highly addictive.
- Noradrenaline
- Dopamine
- Serotonin
- Reuptake
- Reward centres
Almost all drugs target endogenous (______) systems.
- Receptor
Excitatory causes ______
- Depolarisation
Acetylcholine activatea stimulus-gated _____ channeles
- Na+
Inhibitory causes ______
- Hyperpolarisation
GABA activates _____ and ______ channels. This causes hyperpolarisation. (IPSP)
- Cl-
- K+
Can one cell have excitatory and inhibitory synapses?
- YES
EPSP =
IPSP =
- BLEEP (RMP)
- BLOOP (RMP)
Local Synaptic Potentials (EPSPS + IPSPS) summate at the ___ ___, and an action potential is either generated or not.
- Axon hillock
EPSP + EPSP =
- Big EPSP (larger depolarisation)
- AP generation all depends on threshold being reached or not
EPSP + IPSP =
- Nothing (they eliminate each other)
- AP generation all depends on threshold being reached or not
What is spatial summation?
- We receive different signals at different sides of a neuron, at the axon hillock, both signals are summated
- Signals come from DIFFERENT places
- AP is generated if neuron is above threshold
What is temporal summation?
- Signals arriving at the same synaptic knob within a short time range of each other integrate
- Takes more time for repolarisation of local potentials if an AP is generated
What happens if excitatory and inhibitory signals arrive at the same time?
- AP generation all depends on threshold being reached or not