Lecture 4- Neurological Viruses Flashcards
The Eastern equine encephalistis (EEE) virus AND the Venezuelan equine encephalitis virus are from the… family and their genomes are…..
Are they enveloped?
- Togaviridae
- (+)ssRNA
- yes
West nile virus is from the… family and its genome is…
is it enveloped?
- Flaviviridae
- (+)ssRNA
- yes
Rabies is from the … family and its genome is…
is it enveloped?
- Rhabdoviridae
- (-)ssRNA
- yes
Selected togarviruses and flaviviruses are transmitted through a.. such as… Examples of reservoirs are…. And transmission requires…. in the vector
- vector
- mosquitoes, culiseta, aedes, culex, ticks
- birds, small mammals
- replication
Both EEE and VEE use…. to enter cell and… it is then dumped into the…
- receptor mediated endocytosis
- fusion
- cytoplasm (where everything occurs)
When a VEE or EEE virus is introduced through the bite of an arthropod, it infects cells locally and then is carried by…. to… and then it can get to the… where it gets to the… and crosses the… by an unknown methpd
- Langehan cells
- lymph node
- bloodstream
- CNS
- BBB
Incubation period of EEE and VEE is…
4-10 days
The systemic disease of EEE and VEE has symptoms of… and lasts… until full recovery
- chills, fever, malaise, arthralgia
- 1-2 weeks
When EEE or VEE cause encephalitic disease, the symptoms are…
-fever, headache, irritability, restlessness, vomiting, diarrhea, convulsions, coma
… of encephalitic cases (from EEE or VEE) die from the disease 2-10 days after onset
1/3
Those who recover from encephalitic disease (from VEE or EEE) will have long term sequelae such as
seizures
personality disorders
paralysis
Is there a vaccine available for EEE/VEE?
yes but only if traveling/military personnel
live attenuated TC-83 and
inactivated C-84
Is there treatment for EEE or VEE?
No, mosquito control is important
EEE is located in the… U.S. and is maintained in a cycle between …. and… in freshwater hardwood swamps
- southeast
- Culiseta melanura mosquitoes
- avian hosts
… is not considered to be an important vector of EEEV to humans because it feeds almost…
- Cs. melanura
- exclusively on birds
Incubation of West nile virus
2-14 days (short)
… % of people have asymptomatic infections with West nile virus
80%
Illness occurs in about… % of West nile infections and the symptoms are…. and the duration is…
- 20%
- fever, headache, fatigue
- 3-6 days
West nile virus causes … in less than 1% of cases
neuroinvasive
The neuroinvasive disease from West nile causes…
aseptic meningitis, encephalitis, flaccid paralysis, altered mental state, tremors
50% of survivors of neuroinvasive dz from west nile virus have… 12 months later
long term sequlae
Are there any vacccines or treatments for west nile virus?
no (mosquito control important)
West nile virus has been seen in what part of the U.S.
all
… are the main transmitters of west nile virus
Culex sp. mosquitos
