antibacterial immunity Flashcards
both … and… are critical for extracellular bacteria (e. coli, staph, strep, pseudo)
innate and adaptive
… attacks invaders outside the cell
B
… attacks invaders inside cell
T
phagocytosis of extracellular bacteria, .. and… will do this
neutrophils and macrophages
High affinity receptors in recognition of microbe by phagocyte
mannose receptor
mac-1 integrin
scavenger recep.
scavenger receptor binds microbe directly like mannose but does not bind to
mannose
mannose attaches
directly
mac-1 integrin binds microbes…. with complement proteins
opsonized
… is derived from greek word meaning “to prepare for eating”
opsonin
opsonin’s can be…
antibodies
complement proteins
lectin
After engulfment and formation of phagosome there is fusion with … and…
lysosome and phagosome
respiratory burst is when
activated macrophages and neutrophils will convert molecular oxygen into ROS
Th1 make
inflammatory cytokines
Th2 make
B cell promoting cytokines
CD4+ T cells make inflammatory cytokines.. and… which promote
IFN y
TNF alpha
CD4+ produce cytokines … …. and ..
IL 4
IL5
IL10
th2 is important for…
extracellular defense
… immune response is dominant rather than antibody response
cell mediated
both… are involved in intracellular pathogens
innate and adpative
adaptive for intracellular
CD4
CD8
innate for intracellular
dendritic
NK
macrophage/neutrophils
adaptive for extracellular
B cells and antibody IgG T cells (indirect by CD4)
innate for extracellular
macrophages
neutrophils
complement
dendritic are..
professional APCs that present antigen to T cells.
to LN
