Lecture 3- Hepatitis Viruses

Question 1

Typically, RNA viruses replicate in the… and DNA viruses replicate in the… But the exceptions are… viruses which are DNA virus replicate in the … and … which are RNA viruses but replicate in the…

Answer 1

• cytoplasm
• nucleus
• Pox
• cytoplasm
• influenza
• nucleus

Question 2

Hepatitis viruses all target the.. they primarily infect and replicate in… Some cause … infections but some cause…

Answer 2

• liver
• hepatocytes
• acute
• chronic

Question 3

Hepatitis viruses that are enveloped

Answer 3

B, C, and delta

Question 4

Hepatitis viruses that are non enveloped

Answer 4

A and E

Question 5

Hepatitis viruses that are (+)ssRNA

Answer 5

A, C, and E

Question 6

Hepatitis viruses that are (-)ssRNA

Answer 6

delta

Question 7

Hepatitis viruses that has circular dsDNA

Answer 7

B

Question 8

Hepatitis virus from the Picornavisidae family

Answer 8

A

Question 9

Hepatitis virus from the Hepadnaviridae family

Answer 9

B

Question 10

Hepatitis virus from the Flaviviridae family

Answer 10

C

Question 11

Hepatitis virus from the Deltaviridae familt

Answer 11

delta

Question 12

Hepatitis virus from the Calciviridae family

Answer 12

E

Question 13

Which hepatitis viruses are transmitted by fecal oral route?

Answer 13

A and E

Question 14

Which hepatitis viruses are transmitted by sexual route?

Answer 14

all

Question 15

Which hepatitis viruses can be transmitted by vertical route? (mother to child)

Answer 15

B, C and D

Question 16

Which hepatitis viruses are transmitted by Parenteral route? (needles)

Answer 16

all

Question 17

Which hepatitis viruses are rare in the US

Answer 17

D and E

Question 18

Hepatitis… has 0 chronic liver disease deaths associated with is, Hepatitis…. has some chronic liver disease deaths associated with it and Hepatitis …. has chronic liver disease deaths associated with it most of the time

Answer 18

A
B
C

Question 19

Hepatitis B is from the … family and has …. DNA and is the smallest of the human viruses. And is it enveloped?

Answer 19

• Hepadnaviridae
• double stranded
• Yes

Question 20

The unique feature of Hepatitis B is that it has a double stranded DNA but it also has a…. protein, which is an RNA dependent polymerase

Answer 20

reverse transcriptase

Question 21

Can hep B be grown in cell culture?

Answer 21

No

Question 22

Hep B has a… which must be turned into… which is the template for transcription

Answer 22

rcDNA (replication competent)

cccDNA (completely circualized competent DNA)

Question 23

Hep B produces many…. which are present in the bloodstream of infected people. This is why it is considered a “sloppy” disease

Answer 23

empty particles

Question 24

The routes of infection of Hep B are… and…

Answer 24

sexual and through drug use

Question 25

The incubation period for Hep B is.... days which is considered a... incubation period

Answer 25

30-180 | long

Question 26

The onset symptoms of Hep B are...

Answer 26

``` general malaise anoraxia vomiting fatigue cough serum-like sickness ```

Question 27

THe clinical symptoms of Hep B are... and elevated .... levels

Answer 27

Jaundice | ALT (alanine transaminase)

Question 28

Recovery for Hep B is approximately... months after onset of jaundice

Answer 28

3-4

Question 29

Chronic disease occurs in.... % of Hep B cases. Confirmation is by the presence of.... in blood for >6 months and is marked by a poor... response

Answer 29

- 5 - HBsAg - IgG

Question 30

Is there a vaccine available for Hep B?

Answer 30

Yes

Question 31

The vaccine for Hep is is the first..... vaccine approved for use in humans but it requires multiple.... and is not effective against....

Answer 31

- recombinant - inoculations - chronic infection

Question 32

Treatment of Hep B is.... therapy or.... analogs such as...

Answer 32

- interferon alpha - nucleoside - adefovir, lamivudine, tenofovir

Question 33

Hep D is rare and is a .... agent which the only other example of this is.... virus . Hep D requires active... infection and has an RNA genome that encodes...

Answer 33

- subviral - adeno-associated - HBV - single protein

Question 34

Hep C is from the.... family and its genome which means the genome can serve as a template for translation. And the virion is...

Answer 34

- Flaviviridae - (+)ssRNA - enveloped

Question 35

In Hep C, ... is the mechanism that the virus gets into the cell by. Ribosomes recognize ... that is has

Answer 35

receptor binding endocytosis | -IRES (internal ribosome entry site)

Question 36

Hep C typically has ... signs and symptoms than HBV but chronic infections are....

Answer 36

- milder | - much more common (80%)

Question 37

Hep C can cause.... disease which is called mixed... which is when the antibody and virus complexes deposit in other tissues eliciting an immune response and subsequent tissue damage

Answer 37

- Extrahepatic | - cryoglobulinemia

Question 38

Treatment for Hep C is a new product, ....which is on the market to treat some genotypes for chronic disease

Answer 38

ZEPATIER

Question 39

Is there a vaccine for Hep C?

Answer 39

no

Question 40

Infection of Hep A is caused by ... it then is absorbed through.... and moves to liver via portal system

Answer 40

- ingestion of fecally contaminated food or water | - intestine

Question 41

Incubation period of Hep A is... days

Answer 41

15-40

Question 42

Symptoms of Hep A.... which resolve in 8 weeks post infection

Answer 42

malaise anorexia vomiting jaundice

Question 43

Hep A is more severe in...

Answer 43

adults

Question 44

Is there a vaccine for Hep A?

Answer 44

Yes- | Havrix, Vaqta killed/inactivaed vaccine

Question 45

Hep E virus causes.... and... hepatitis

Answer 45

foodborne and waterborne

Question 46

Hep E disease is similar to .... but can be distinguised by....

Answer 46

- Hep A | - serology or antibody tests

Question 47

A hep E infection can be life threatening for...

Answer 47

pregnant women

Question 48

Is there a vaccine for Hep E?

Answer 48

no

Question 49

Incubation period for Hep C

Answer 49

60-120 days