LECTURE 34 Flashcards
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anterior pituitary hormones?
GH AcTH TSH FSH LH MSH
posterior pituitary hormones?
ADH
Oxytocin
Adrenal Cortex hormones?
cortisol
aldosterone
androstienedione
thyroid gland hormones?
thyroxine (T4)
tri-iodothyronine (T3)
calcitonin
pancreas hormones?
insulin
glucagon
somatostatin
parathyroid hormone?
parathormone (PTH)
liver hormone?
somatomedin
hormones produced by the ovaries?
estrogens, progesterone
hormones produced by the testes?
testosterone
hormones produced by the placenta?
estrogens, progesterone, HCG
3-180 aa’s, long, fast, specific, short lasting, 2nd messengers, most hormones? polypeptides or steroids
polypeptides
cholesterol based, slow, broad functions, long lasting, gene expression, used for growth and maturation? polypeptides or steroids
steroids
what converts cholesterol to pregnenalone and then what is the enzyme that converts this to estrogen, testosterone, cortisol and aldosterone?
desmolase, rate limiting
hydroxylate isomerize
what is the fate of carbohydrate?
it gets turned into glucose sent to liver, muscle, and adipocytes which then becomes CO2 + ATP, glycogen
what is the fate of protein?
it gets turned into amino acid sent to the muscle and adipocytes when then becomes CO2+ATP, glycogen, and protein
what is the fate of fat?
it gets turned into FFAs then sent to adipocytes to become CO2+ATP and triglycerides
in fasting state, glycogen is sent to the liver which breaks it down to glucose and used by what organ?
brain
in fasting state, protein is sent to the muscle which breaks it down to amino acids and used by what organ?
liver
in fasting state, triglycerides are broken down by adipocytes into FFAs and then used by what organs?
muscle
liver
others
insulin and glucagon are steroids or polypeptides? where are they from?
polypeptides
islets of langerhans
this peptide is measured in the blood to get more accurate measure of insulin release?
c-peptide
insulin circulates in the blood largely in a bound or unbound state?
unbound state
insulin has what ind of effect on hepatocyte glucose transporter?
no effect
these organs use insulin independent glucose transporters? they keep working during bad times too
brain, kidney and GI tract
increased fat metabolism often leads to what disease?
atheroscherosis and other circulatory problems like heart attack, stroke, gangrene and blindness
what is the best treatment for insulin type I or juvenile onset diabetes?
insulin injections
what is the best treatment for insulin type II or adult onset diabetes?
diet
describe ADH?
polypeptide hormone made by the magnocellular neurons of the supraoptic nucleus of the hypothalamus
what stimulates the release of ADH?
osmoreceptors in the hypothalamus
(increase osmolarity, decrease BP and BV)
arterial baroreceptors reflex
cardiopulmonary reflexes (low blood volume)
what are the actions of the ADH? what disease is associated with this hormone?
receptors on cells of renal DCT and collecting duct
aquaporin-2
arteriolar constriction
diabetes insipidus
what type of hormone is growth hormone, steroid or polypeptide?
polypeptide