LECTURE 33

Question 1

what do receptors recognize?

Answer 1

extracellular signals

Question 2

these are stimulated or inhibited by these and they produce what type of messengers?

Answer 2

effectors

intracellular 2nd messengers

Question 3

what are the three types of receptor effector relationships?

Answer 3

R and E are same protein
-steroids
-tyrosine kinase
R and E are subunits in the same protein complex
-nicotinic Ach receptor
R and E are separate proteins
-most common type

Question 4

TK receptors are often for anabolic signals like? TK is important in regulating this?

Answer 4

insulin, GF

differentiation and proliferation

Question 5

this inactivates GTPase activity in g-proteins, so they remain activated resulting in severe diarrhea and death?

Answer 5

cholera toxin

Question 6

for the phospholipase C cascade, this second messenger is hydrophobic and remains in the cell membrane?

Answer 6

DAG

Question 7

for the phospholipase C cascade, this second messenger is hydrophilic and enters the cytosol?

Answer 7

IP3

Question 8

this molecule is implicated in preventing platelet aggregation?

Answer 8

nitric oxide

Question 9

what are the contributing factors that exhibit decreased sensitivity?

Answer 9

receptor phosphorylation
receptor mediated endocytosis
g-protein

Question 10

T/F, there is a lot of cross talk in signal cascade?

Answer 10

T