LECTURE 28 WATER SOLUBLE VITAMINS II

Question 1

this water soluble vitamin in the decarboxylation of of alpha keto acids and by transketolase?

Answer 1

thiamine

Question 2

what are the two active forms of riboflavin and what are the reducing enzymes?

Answer 2

flavin mononucleotide (NADH Q reductase)
flavin adenine dinucleotide (complex II)

Question 3

what are the two active forms of niacin?

Answer 3

NAD

NADP

Question 4

some of this water soluble vitamin can be synthesized from tryptophan?

Answer 4

niacin

Question 5

use of this water soluble vitamin can be used to treat hyperlipoproteinemia?

Answer 5

niacin by decreasing VLDLs and LDLs

Question 6

lack of this vitamin is associated with diseases that affect neural function because the brain glycolysis and TCA are impaired?

Answer 6

beriberi

wernicke Korsakoff syndrome

Question 7

this vitamin is used to treat patients with alcoholism because thiamine levels are deficient?

Answer 7

thiamine

Question 8

this vitamin is covalently bound to lysine?

Answer 8

biotin

Question 9

the active form of this vitamin is a component of coenzyme A? note: deficiency is rare

Answer 9

pantothenate

Question 10

what is the active form of folate? what is it inhibited by>

Answer 10

THF

methotrexate

Question 11

what is significant about methotrexate?

Answer 11

antineoplastic agent and it limits purine synthesis

Question 12

how do microorganisms make folate from PABA? what limits this enzyme?

Answer 12

dihydrofolate synthase

sulfonamides

Question 13

what does a folate deficiency do to pregnant women?

Answer 13

causes neural tube defects

Question 14

what two reactions is cobalamin (B12) used for?

Answer 14

synthesis of methionine

metabolism of methylmalonyl CoA

Question 15

effect of intrinsic factor deficiency?

Answer 15

pernicious anemia

Question 16

this vitamin is used for the 3 precursors of this active form? what is this used for?

Answer 16

pyridoxal phosphate

a cofactor in many reactions of amino acid metabolism

Question 17

this vitamin is important in hydroxylation reactions which is critical for collagen synthesis, like in the production of hydroxyproline and hydroxylysine? who advocated for mega doses?

Answer 17

ascorbate (vitamin C)

pauling

Question 18

what is the significance of vitamin C? these two vitamins also have the same significance?

Answer 18

antioxidant
inactivates free radicals
protects membranes from damage

B-carotene and vitamin E