Lecture 30 - Ox Phos Regulation Flashcards
ATP Synthase is also known as “_______.”
Complex V
The F1 subunit of ATP synthase is comprised of:
alpha 3, beta 3, gamma, delta, and epsilon subunits
Wha F1 subunits are arranged in a hexameric ring?
alpha and beta
The ___ subunit of the hexameric F1 ring is catalytically active.
beta
Above the alpha and beta subunit ring, there exists a “stalk” that connects the F1 to the F0 subunits. What comprises this “stalk?”
gamma and epsilon proteins
Each ____ subunit in the F1 region has a distinct region connected to the stalk.
beta
Conformation of the __ subunits occurs as H+ flow through the ATP synthase.
beta
What are the three steps of ATP synthesis in the enzyme ATP synthase?
Binding of ADP + Pi (L conformation)
ATP synthesis (T conformation)
Release of ATP (O conformation)
The “O conformation” of the beta subunit release the newly synthesized ATP. What co-factors is required for this release?
H+
The “proton conducting unit” of the ATP synthase is the (F1/F0) region.
F0
The F0 region is comprised of what subunits?
The ring c subunits (8-14) and an a subunit.
This enzyme moves newly synthesized ATP from the matrix to the cytosol A. ADP-ATP synthase B. ATP synthase C. Complex V D. ATP-ADP translocase
D. ATP-ADP translocase
This prevents the hydrolysis of ATP by the reverse reaction of ATP synthase.
Inhibitory factor 1
ATP synthase can be uncoupled from oxidative phosphorylation by these proteins.
UCP 1 through 3
Uncoupling of ox-phos occurs in the _______, which is rich in mitochondria.
A. Brown adipose tissue
B. White adipose tissue
C. Principle cells of the kidney
D. Central nervous system
A. Brown adipose tissue
