Lecture 30: Coeliac Disease Flashcards
1
Q
What happens in coeliac disease?
A
Autoimmune destruction of villi in small intestine
Villous flattening/atrophy
2
Q
What can coeliac disease lead to?
A
Deficiencies in;
Iron, B12, folate
Weight loss
3
Q
What kind of diarrhoea can coeliac cause?
A
Osmotic diarrhoea
4
Q
At a histological level what is found in coeliacs disease?
A
- Intraepithelial lymphocytosis
- Villous blunting
- Crypt hyperplasia
5
Q
What are the celiac antibodies?
A
Anti-TTG (Recomended)
Anti-EMA
Anti-DGP
Anti-gliadin (not used as too inaccurate)
6
Q
Why is there mal-absoprtion in coeliacs?
A
Loss of brush border enzymes
7
Q
Whats a skin condition associated with coeliacs?
A
Dermititis herpetiformis
