Lecture 3 B7 Flashcards
Apical/Tubular epithelial cells
faces urine
Basal/basolateral epithelial cells
faces interstitium
Paracellular
between the cells
Transcellular
across the cell
Active transport
Against gradient (uses ATP)
Passive transport
with gradient (no ATP)
Simple diffusion
Due to gradient also bulk flow (ultrafiltration)
Carrier mediated
Needs a carrier protein… Has a Tm
True/False: Nearly everything that the kidney filters (filters about 180 L of plasma a day) is reabsorbed
True
Ability to adjust reabsorption rate to match the filtered load
Glomerulotubular balance
Most Na+ movement is transcellular
Active transport
Sodium diffuses in on apical side and pumped out basal lateral side
Where is it only permeable to water? Water is reabosrbed due to osmotic forces.
Vol of tubular fluid decreases
Solutes remain
Osm increases
Thin Descending loop of Henle (DTL)
Where is it impermeable to water? Not a whole lot going on.
Thin ascending loop of henle (ATL)
Where is it impermeable to water? but lots of transport, active, passive, paracellular, and transcellular (helps generate hyperosmotic gradient in tissue)
Thick ascending loop of henle (TAL)
WHere is it impermeable to water? keeps diluting tubular fluid… with lots of transport (active, passive, paracellular, transcellular)
Early distal tubule
(Na-Cl-K symporter is here)
(Na-Cl symporter is here)
