LEC 2 Filtration B7

Question 1

Filtration occurs only in the __________

Answer 1

Glomerulus

Question 2

Rate of filtration is measured by _________

what is a way of measuring this?

Answer 2

GFR

Measure clearance of inulin or blood creatinine levels

Question 3

What filters?

Answer 3

Water, small solutes
In proportion to their FREE plasma concentration
Tubular fluid is same as plasma (except proteins)

Question 4

What doesn’t filter?

Answer 4

Plasma proteins (mostly) and anything bound to the plasma proteins

Question 5

Excretion = what?

and what effect does filtered load have when it is greater, or less than, or equal to Excretion?

Answer 5

Excretion = Filtered load + secretion -reabsorption
If excretion > filtered load then net secretion had to occur
If Excretion < filtered load then net reabsorption had to occur
If excretion= filtered load then there was no net transport

Question 6

True/False: Generally there is very low pressure in Bowman’s space, generally no osmotic pressure there.

Answer 6

True

Question 7

Glomerular capillaries have _____ control of Pgc and RBF.

Answer 7

local
Pressure in glomerular capillaries
Renal blood flow

Question 8

True/False: Changes in afferent diameter alter GFR and RBF in opposite ways.

Answer 8

False: in the same way
Constrict afferent= reduce Pgc, GFR and RBF
Dilate afferent= increase Pgc, GFR and RBF

Question 9

True/False: Changes in efferent affect GFR and RBF in opposite ways.

Answer 9

True
Constrict efferent= Increase Pgc and GFR but reduce RBF
Dilate efferent= Reduce Pgc and GFR but increase RBF

Question 10

Renal blood flow is calculated by what?

Answer 10

PAH (measure renal plasma flow)

Question 11

Kidney is able to control its own blood flow in response to change in pressure by what?

Answer 11

Autoregulation

Question 12

This mechanism of autoregulation is

• at the level of the smooth muscle
• reacts to blood flow/pressure changes
• response of smooth muscles to stretch

Answer 12

Myogenic response

Question 13

THis mechanism of autoregulation is

-the nephron senses its own flow and adjusts

Answer 13

Tubuglomelular feedback

Question 14

This mechanism of autoregulation is

-Renin released from kidney, causes release of other hormones

Answer 14

RAAS system

Question 15

If you have more sodium in tubular fluid there is ____ activity of Na/K ATPase. and there is more or less adenosine?

Answer 15

More

More adenosine

Question 16

Adenosine binds to smooth muscle cells and causes constriction of _______ arteriole. Reduces ____ and ____ and __________ production.

Answer 16

afferent arteriole

GFR and RBF and renin production (which makes less Ang II which lowers pressure and GFR)

Question 17

Not enough NaCl dilates afferents and increases or decreases renin secretion?

Answer 17

increases renin secretion

Question 18

True/False: Release renin when GFR goes down

Answer 18

True

Question 19

True/False: RAAS gets set off when the effective circulating volume drops

Answer 19

True

Question 20

Myogenic and Macula densa work mostly on what arteriole?

Answer 20

AFFERENT

Question 21

AngII acts preferentially on what arteriole?

Answer 21

EFFERENT

Question 22

Sugar your body cant metabolize

Answer 22

Inulin