Lecture 25--bacterial infection Genitourinary Tract Flashcards
GU require ___ transmission
direct contact (usually sex)
top 10 STIs
trichomonas, HPV, pubic lice, chlamydia, neisseria gonorrhea, vaginosis, herpes, AIDS, syphilis, hep B
what does gonorrhea mean?
flow of seed
gram neg cocci in pairs, fragile, humans only host and reservoir
neisseria gonrrhea
point of entry for gonorrhea is __ in F and ___ in M
vagina; urethral canal
___% chance of disease after single sex contact, < ____ bacteria starts infection
30-50; 1000
pathogenesis of gon.?
attach to epithelial cells–>invade cells and enter sub-epithelial, release LPS and inflammatory response–>tissue damage allow free bacteria release into genital secretions
disease symptoms for F?
often asymptomatic, mild inflame, burning when urinate
disease symps of M?
urethral canal inflame, painful urine, discharge pus
__% of gon. infection result in disseminated gon., which involves these symps:
1; skin rash, pus lesions, heart/liver infections, joint inflammation
complications of gon.?
when untreated, males have urethral scarring/infertility, females have scarred fallopian tubes and pelvic inflammatory disease
transmission of N. gon. to infant during vag birth results in:
eye infection
diagnose gon.?
nucleic acid amplification test on urine specimens (screening for high risk, asymptomatic and confirmatory for symps suggest gonorrhea)
standard treat for gon.?
azithromycin and ceftriaxone
how come no immunity for gon.?
switches between diff types of pili
cause of syphilis, gram neg. spirochete, transmit only by direct contact
treponema pallidum
usual point of entry for syphilis is into ____ tissue of gen. tract, and it is ___ entry that requires pre existing tissue cut or abrasian
sub epithelial; passive
four stages of syphilis
prim., sec, latent, tert
primary syph?
multiply slowly at site of entry, proteins and LPS cause inflame, painless open sore/lesion called chancre forms at site of entry many days after contact
due to inflamm rxn of immune, vary in size, contain large numbers live treponema and can cause further transmission syphilis
chancre
secondary syphilis occurs ___ wks after chancres heal and involves ___ of treponema via ____
5-10; spread; blood
secondary syphilis has ___ symptoms and wide spread ____
flu-like; skin rash
latent stage can last for life without symps in ___% population or else progress to ____
70; tertiary
what is tert syph?
reactivation later in life, little risk transmission, resume growing at lower lvl, delayed hypersensitivity rxn (lots of tissue damage, gummas, cardiovas, nervous sys)
