Lecture 2: Respiratory Flashcards
Where is olfactory epithelium located?
the superior aspect (roof) of the nasal cavity
What type of epithelium is olfactory epithelium?
pseudostratified columnar
List layers (3) of olfactory epithelium from outer to inner
1) Sustentacular (supportive) cells
2) Olfactory cells containing non-motile cilia (9+2)
3) Basal stem cells = neuronal cells with axons
What do non-motile cilia NOT have?
dynein arms
What does the larynx consist of?
- Epiglottis
- False vocal cord
- True vocal cord
What type of epithelium covers the anterior surface of the epiglottis?
stratified squamous
What type of epithelium covers the posterior surface of the epiglottis?
ciliated pseudostratified columnar (aka respiratory epithelium)
The false vocal cord is made up of which type of epithelium?
ciliated pseudostratified columnar
The true vocal cord is composed of which type of epithelium?
stratified squamous
Which structures are located in the underlying CT of the larynx?
- Mucous glands = secrete mucous
- Elastic cartilage = stains dark purple due to elastic fibers
What is the function of cilia in the pharynx?
- Straighten and pushes against the mucus layer as it beats toward the pharynx
- Bends below the mucous into the thin watery layer on recovery beat
What would happen if cilia is damaged?
- decreased ability to clear mucous out of the respiratory system = leading to build up of mucous
- damage to epithelium = cells shift and an increase in basal cells replace damaged cells
What does the loss of normal respiratory (ciliated pseudostratified columnar) epithelium lead to?
lung diseases, cancer
Where is the trachea located?
anterior to esophagus
What composes the posterior wall of the trachea?
smooth muscle bridging the gap in the c-shaped cartilages
What type of epithelium covers the trachea?
ciliated pseudostratified columnar
What does cystic fibrous cause?
- Defective Cl- protein = decreased Cl- secretion = increased Na+ absorption which draws water out of mucous = abnormally thick mucous that is difficult to clear out of lungs
What type of epithelium lines bronchi?
ciliated pseudostratified columnar epithelium
What does bronchi contain?
- hyaline cartilage
- mucous gland
- smooth muscle
Which respiratory structures are the ONLY structures to have hyaline cartilage?
Larynx, bronchi and trachea
What type of epithelium lines the terminal bronchioles?
shorter ciliated pseudostratifed columnar epithelium
What type of epithelium lines the respiratory bronchioles?
simple cuboidal epithelium
What type of muscle do bronchioles contain?
smooth
Where are Clara cells located?
terminal bronchioles
What is the function of Clara cells?
produce lipoprotein that prevents adhesion of the wall in the event of tubular collapse
What are the cellular components of the alveolar wall? What are their shapes, functions, and type of epithelium?
- Type 1 pneumocytes = squamous = gas exchange
- Type 2 pneumocytes = cuboidal = make surfactant
- Fibroblasts = spindle shaped
- Macrophages = irregularly shaped
List the symptoms (5) of asthma?
- inflammation and excess mucous secretion obstruct airways
- allergic reaction = IgE binds to mast cell = releases histamines
- Vasodilation
- Hypersecretion of mucus
- Bronchoconstriction
What does emphysema cause?
- Destruction of alveolar walls = insufficient gas exchange during respiration
- Loss of elastic weakens alveolar wall= enlarged air spaces
What is #1?
Bone
What is #2?
Venous Plexus
What is #3?
Supportive cells
What is #4?
Basal cells
What is #5?
Olfactory cells
What is #6?
Bowman’s glands
What is #1?
Supportive cells
What is #2?
Olfactory cells
What is #3?
Basal cells
What is #1?
Pharynx
What is #2?
Epithelium (Stratified squamous)
What is #3?
Epiglottis
What is #4?
Elastic cartilage
What is #4?
Elastic cartilage
What is #5?
Glands