Lecture 2 (Lead and Cadmium Poisoning) Flashcards
what are symptoms of metal fume fever?
similar to flu
fever, chills, nausea, headache, fatigue, muscle ache
generally lasts 1-2 days
___ for metal fume fever builds up during the week
tolerance
metal fume fever results from ___ response to metal oxides…
acute response
zinc, cadmium, manganese, chromium, copper, lead
what blood lead level usually kills patients?
130 ug/dL
what is the normal blood level concentration as established by the CDC?
5 ug/dL
what causes Itai-Itai disease?
cadmium poisoning
how does cadmium exposure occur?
through fish and cigarettes and drugs
describe treatment for lead poisoning
why is pause-chase necessary?
EDTA draws out lead from body and chelates it
pause –> allows lead to come out from bone
chase –> EDTA treatment to deal with the lead
what is the key reason behind Alzheimer’s D?
extracellular B-amyloid proteins
intracellular Tau proteins
what were the early signs of lead poisoning in Nigerian gold rush?
ducks die
