Lecture 2

Question 1

What are the two main parts of a virus

Answer 1

protein and nucleic acid

Question 2

What is the protein shell called

Answer 2

capsid

Question 3

What is the complete virus particle called?

Answer 3

virion

Question 4

What does an enveloped virus have that a naked capsid virus does not?

Answer 4

glycoproteins and membrane

Question 5

What 3 types of damage do capsids protect against?

Answer 5

physical damage, chemical damage, and enzymatic damage

Question 6

What shows the intensity of nucleic acid bands?

Answer 6

protein electrophoresis

Question 7

Why do viruses have repeated capsid subunits?

Answer 7

less nucleic acid to code, and it can assemble easily and efficiently

Question 8

Why is it difficult to purify native (non-denatured) viral proteins?

Answer 8

they easily bind to each other and precipitate from the solution

Question 9

Where is the envelop derived from?

Answer 9

Host lipid bilayer

Question 10

What are the three types of host-derived lipid bilayers?

Answer 10

peri-nuclear, de novo, and plasma/cytoplasmic

Question 11

What codes for glycoproteins?

Answer 11

viral genes

Question 12

Where are carbohydrates formed?

Answer 12

Endoplasmic reticulum

Question 13

multiple protein subunits form spikes or peplomers

Answer 13

multimeric

Question 14

usually causes cold-like symptoms but can also cause more severe diseases like pneumonia and bronchiolitis

Answer 14

respiratory syncytial virus

Question 15

an inflammation of the small airways in the lung with increased mucus production and bronchospasms

Answer 15

bronchiolitis

Question 16

contraction and relaxation of the small airways

Answer 16

bronchospasms

Question 17

How do RSV infections start out in children?

Answer 17

fever, mild cough, congestion

Question 18

which nucleocapsid shape is almost spherical?

Answer 18

icosahedral

Question 19

what shape is picornavirus?

Answer 19

icosahedral

Question 20

which 2 viruses have 2 capsid shells?

Answer 20

reovirus and orbivirus

Question 21

What kind of symetry does the tobacco mosaic virus have?

Answer 21

helical

Question 22

Which type of nucleic acid can act as mRNA?

Answer 22

+

Question 23

Which type of NA viruses have a larger range in genome size?

Answer 23

DNA

Question 24

How many segments do reoviruses, rotaviruses and orbiviruses have?

Answer 24

10-12 dsRNA

Question 25

How many segments does influenza genome have?

Answer 25

8

Question 26

How many segments does bunyavirus have?

Answer 26

3

Question 27

How many segments does arena virus have?

Answer 27

2

Question 28

What is special about segmented genomes?

Answer 28

they can reassort

Question 29

herpes and retroviruses have 400 bases that are similar on each end. this is called…?

Answer 29

terminal redundancy

Question 30

Name the DNA viruses

Answer 30

Parvoviridae, papillomaviridae, adenoviridae, herpesviridae, poxviridae, hepadnaviridae

Question 31

DNA or RNA as messenger +RNA

Answer 31

transfection

Question 32

why aren’t -RNA viruses infectious?

Answer 32

they require virus coded enzymes to make +RNA

Question 33

What kind of proteins do viruses have?

Answer 33

Structural, nonstructural, glycoproteins, hemagluttins, (possibly cell enzymes)