Lecture 2 Flashcards
What are the two main parts of a virus
protein and nucleic acid
What is the protein shell called
capsid
What is the complete virus particle called?
virion
What does an enveloped virus have that a naked capsid virus does not?
glycoproteins and membrane
What 3 types of damage do capsids protect against?
physical damage, chemical damage, and enzymatic damage
What shows the intensity of nucleic acid bands?
protein electrophoresis
Why do viruses have repeated capsid subunits?
less nucleic acid to code, and it can assemble easily and efficiently
Why is it difficult to purify native (non-denatured) viral proteins?
they easily bind to each other and precipitate from the solution
Where is the envelop derived from?
Host lipid bilayer
What are the three types of host-derived lipid bilayers?
peri-nuclear, de novo, and plasma/cytoplasmic
What codes for glycoproteins?
viral genes
Where are carbohydrates formed?
Endoplasmic reticulum
multiple protein subunits form spikes or peplomers
multimeric
usually causes cold-like symptoms but can also cause more severe diseases like pneumonia and bronchiolitis
respiratory syncytial virus
an inflammation of the small airways in the lung with increased mucus production and bronchospasms
bronchiolitis
contraction and relaxation of the small airways
bronchospasms
How do RSV infections start out in children?
fever, mild cough, congestion
which nucleocapsid shape is almost spherical?
icosahedral
what shape is picornavirus?
icosahedral
which 2 viruses have 2 capsid shells?
reovirus and orbivirus
What kind of symetry does the tobacco mosaic virus have?
helical
Which type of nucleic acid can act as mRNA?
+
Which type of NA viruses have a larger range in genome size?
DNA
How many segments do reoviruses, rotaviruses and orbiviruses have?
10-12 dsRNA
