Lecture 2 Flashcards
Do waves of innate and adaptive response vary depending on pathogen and location
Yes
Why is the immune system so complicated
Brief description of role of b lymphocytes
Do all living things have pathogens?
Are pathogens In cells visible or invisible to Ab and how does IS target pathogen in cells
Pathogens in cells are mostly invisible to Ab so MHC molecules bind antigens in cells and present them on cell surface
MHC= major histocompatability complex. Known as human leukocyte antigen (HLA). Class 1 gene products function = present endogenous peptides to responding CD8+ T cells
Class II= have restricted expression and process exogenous peptides for presentation to CD4+ helper T cells
Class III= contains genes that encode for immune regulatory molecules eg tumour necrosis factors (TNF) like C3, C4 and C5 of complement and heat shock proteins
What recognises CD4 and CD8
How are TCRs generated
What do naive T-cells need to become activated
Whats Class I response for adaptive immune system
Class II response to pathogen in adaptive immune system
How do NKC contribute to adaptive immune response
Where are the majority of gamma delta T cells and how do they aid the adaptive IR
what’s adaptive and anticipatory IM
Are their different types of adaptive IS in vertebrates
What processes is thought to have given rise to two adaptive immune systems in vertebrates
Name other adaptive immune responses that aren’t in vertebrates
What does CRISPR stand for and what are spacers
In principle spacers are like dicer systems but with information stored in germline
Briefly explain how CRISPR works
Difference between acquired and anticipatory immunity
In humans and mice what single system originated all adaptive immunity
Are all the comments of innate immune systems recent evolutionary developments
What’s RNA interference and related pathways
What’s the most important feature of host responses and what maintains it (eg in innate and adaptive)
Diversity
What are the three kinds of innate immunity and two kinds of adaptive
How do innate and adaptive systems come about
