L 5 - Humeral Immunity Flashcards
How do lymphocytes generate receptors
How did the Ig locus evolve
What’s BCR and what’s it’s structure
Modes of B cell activation
What are plasma cells
What directs Ig switching in b cells
Average percentage of B cells that make memory vs PC
Why do secondary vaccinations aid in protective immunity
What is fc region of an antibody and 2 key functions
Fc= tail region of antibody that interacts with cell surface receptors called fc receptors and some proteins in complement system. Region allows Ab to activate IS eg through binding receptors
Main effector functions of antibodies
Define phagocytosis and its stages
What’s opsonisation and what’s it enhanced by
What are mast cells and what do they release after Fc£R cross-linking
Mast cells = immune cells from myeloid lineage. Arise in BM and progenitor cells circulate and become home to various tissues, stem cells In tissue can differentiate progenitor into a mast cell
Fc receptor functions for different immune cells eg mast cell, ab, DC
Define complement and name the 2 substances needed for bacteriolytic activity
2 key outcomes from complement activation
2 key outcomes from complement activation
Outline How does complement effect different immune cells and what cytokines are needed for each function eg (activation, release of inflammatory mediators)
Where do most complement components come from
What are the three complement pathways, what stimulates them and what is the outcome of each pathway
Classical, lectin and alternative
What activated the three different complement pathways
How is C5b made in alternative pathway
Describe the process of cell lysis through complement pathway
What are anaphylatoxins and what are their function
Anaphylatoxins = peptides responsible for the acute inflammatory response, including mediating migration and activation of a range of immunocompetent cells to site of pathogen or tissue injury
When CR1 and Fc receptor bind what is enhanced
Complement activation is important for clearing immune complexes, what enhances this
How does MCP and DAF regulate complement
What causes allergic reactions
3 outcomes of IgM and IgG mediated hypersensitivity reactions
Anti-body mediated hypersensitivity reactions is immune reaction in which Ab (IgG or IgM) are directed against cellular or extracellular matrix antigens resulting in cellular destruction or tissue damage
