L 6 - Interface Of Innate And Adaptive Immunity Flashcards
How is opsonization an example of the innate cells being activated by adaptive mechanisms
How is mast cell binding to FC£R receptor an expample of innate cells being activate by adaptive mechanisms
What does transmembrane region of fc receptor bind to, to transducer a signal
What does transmembrane region of fc receptor bind to, to transducer a signal
3 examples of adaptive IS cells that act like innate
What do T and B cells recognise
How are autoantibodies and autoimmunity avoided
Avoid antibody response to our own body by two signal model, 1 signal from Ag on B cell and 1 signal from Thelper. Autoimmunity rare if 2 self reactive cells have to be generated and meet.
BUT
What generates a vaccination response
A- whole bugs
B- subunits
C - subunits + microbial adjuvants
A- good
B- poor
C - good
Can’t get a good immune response without microbial signals
How does APC identify self from non self
Outcome for B cell if 1 activation signal is received vs if 2 signals are present
Outcome if T cell has 2 activating signals vs 1
What are the types of immune cells that can be APC and what do they activate
APC’s activate naive CD4 T cells
Do professional APC need to be activated
Describe DC maturation and migration
What do adjuvants activate
What on the T cell helps prime DC
T cell CD40L (on DC) interacts w CD40 on B cells
After PRR ligation induces DC (APC) maturation what happens
How do tissues influence the immune response eg infected epithelium
What’s the danger hypothesis
