Lecture 19 Flashcards
Heterogametic sex
Males XY
Homogametic sex
Females XX
Y chromosome
Not man genes on it but determines maleness in humans
X chromosome
Larger chromosome with a large number of genes on it
Sex linked genes on which chromosomes
X chromosomes
Non sex chromosomes called what
Autosomes
Barr body
Inactive condensed chromatin remains inactive for a cell- lines progeny
Females have 2 X chromosomes, while males have 1, what happens in women
One of the X chromosomes is always inactivated to form a barr body
X inactivation is a cell -line specific trait
Examples
Calico cats with orange and black patches result from inactivation of one of the 2 X chromosomes in the skin
SRY gene
Gene on the Y chromosome
Master switch that directs development of maleness at an early stage of embryonic development
Basically
Sex determining region of the Y chromosome
Gene codes for sex determining region Y protein
How long for SRY gene to become active
Male embryo the tissues that form reproductive structures don’t begin to differentiate into testes until SRY becomes active
6-8 weeks
Is the SRY a pleiotropic gene
Why
Yes
Affects many tissues in the embryo
Suppresses female differentiation
Also works to develop and maintain secondary sex characteristics in males
One of the best known X linked disorder
Hemophilia
Blood doesn’t clot normally, so any cut or bruise can be life threatening
How to do sex linked traits
Dominant H
Recessive h
X^H X^h cross them
Hemizygous
Only receive one copy of a sex linked gene
Presence of one normal allele will mean ur chilling
One bad one and ur cooked