lecture 16 Flashcards
Discuss herpesvirus morphology
herpesvirus morphology
-enveloped viruses with icosahedral (3D hexagon)
Explain latency/ persistence for herpesvirus
latency/ persistence for herpesvirus
-establishment of latency;
abundant viral gene expression and DNA replication and entry of viral genome and extinction of viral gene expression
-maintenance of latency;
no detection of abundant lytic viral gene expression or viral DNA replication
-reactivation from latency; external stimulus (stress) and productive infection (DNA replication)
the first phase is replicating and the virus will shut down and stop replicating and the virus comes out when you are stressed.
Equid alphaherpesvirus 1 and 4
Equid alphaherpesvirus 1 and 4
very common
EHV 1 causes respiratory disease, abortion and neurological disease
EHV 4 causes respiratory disease and only occasionally causes abortions and neurological diseases.
For Equid alphaherpesvirus state some clinic signs
Equid alphaherpesvirus clinical signs
- coughing
- nasal discharge
- enlargement of mandibular
- anorexia
State some clinical signs of equine herpesvirus myeloencephalopathy
clinical signs of equine herpesvirus myeloencephalopathy
- incoordination of hindlimb
- ataxia or wobbly gait
- urine retention/dribbling
- neurologic signs come before fever respiratory signs
What is the diagnosis of equine herpesvirus myeloencephalopathy 1 & 4
diagnosis of equine herpesvirus myeloencephalopathy 1 & 4
detection of viral genome by using PCR
Explain the vaccination of equine herpesvirus 1 & 4
vaccination of EHV 1 & 4
- both live attenuated and inactivated vaccines
- vaccines reduce abortion and CNS infection.
- DON’T prevent infection
- substantially reduce viral shedding
Discuss equid alphaherpesvirus 3
equid alphaherpesvirus 3
mode of transmission is direct sexual contact and flies carrying infected vaginal discharge
virus produce vesicular and erosive lesion on penis and vulva
virus remains latent
Discuss felid alphaherpesvirus 1
felid alphaherpesvirus 1 causes upper respiratory tract disease conjunctivitis ulcerative keratitis clinical signs: coughing sneezing nasal discharge latency is a thing
For Galli alphaherpesvirus 2
state what disease is causes
host
characteristics
Galli alphaherpesvirus 2
disease cause is Marek’s disease
host; chickens and turkeys etc.
characteristics highly contagious
List the clinical signs of Marek’s disease
clinical signs of Marek’s disease
- latent infection is established in T cells
- depression
- paralysis
- dehydration
- diarrhoea
- nervous system (paralysis of the legs, wings, neck, loss of weight)
- skin (tumours appear in feather follicles)
- Organs (grey-ish white tumours on ovaries, liver etc. and enlarged nerves)
Discuss the virus caused by Sui aplhaherpesvirus 1
Sui aplhaherpesvirus 1
causes Aujeszjy’s disease
causes serve neurological. disease in affected animals
For Aujeszjy’s disease list the clinical signs and the diagnosis
Aujeszjy’s disease
clinical signs
pregnant sows; abort or give brith to weak
feral pigs; no signs of disease
other animal; intense itchiness, become weak, unable to stand, difficulty breathing and die
diagnosis
detection of ag or viral DNA in tissues (brain, spinal cord)
vaccines
controlled by eradication
For Bovine alphaherpesvirus 1 discuss what is caused subtypes characteristics what disease is caused vaccination diagnosis
Bovine alphaherpesvirus 1
genital infections may cause balanoposthitis
BoHV 1-1 subtypes have different virulence
BoHV1-1 more serve causes abortions
BoHV 1.2 doesn’t cause abortions
causes Bovine respiratory disease complex
which is due to environmental factors like stress, transport and immunosuppression cause more likelihood of the an outbreak of the disease
-vaccination; reducing shedding of virus
-detection through viral DNA via PCR
Discuss bovine alphaherpesvirus 5
bovine alphaherpesvirus 5
causes mild respiratory disease
most common in calves
encephalitis following nasal infections or ascending paralysis resulting from genital infections
