Lecture 15 Part II - Anti-inflammatory drugs

Question 1

Physiological effects of glucocorticoids?

Answer 1

regulation of carb, protein and fat metabolism, fluid balance, preservation of systems & homeostasis

Question 2

Pharmacokinetics of GCs?

Answer 2

incr. lung deposition and pulmonary retention, high receptor binding-affinity, rapid clearance

Question 3

Drug mechanism?

Answer 3

intracellular receptor, binds HDAC, alters gene expression, decreasing inflammatory gene transcription

Question 4

GC principle effects?

Answer 4

suppress immune cells, inhibit synthesis, release and expression of cytokines, chemokines, adhesion molecules and lipid midiators involved in inflammatory response, also upregulates b-adrenergic receptors on smooth muscle

Question 5

Oral GC?

Answer 5

Prednisone

Question 6

Cushing syndrome?

Answer 6

hypercortisolism casuing buffalo lump and moon face; obese centre w thin legs and arms

Question 7

Side effects of GC?

Answer 7

hyperglycemia (diabetes), blood pressure, osteoporosis, euphoria, cataracts

Question 8

Leukotrine recpetor antagonists prevent?

Answer 8

aspirin and exercise induced asthma, decrease early and late responses to allergen - also used combined w b-adrenergic agonist for bronchodilation