Lecture 11 - Gaseous Exchange and Transport Flashcards
Pressure of O2 cascade?
160mmHg in atmosphere to 1mmHg at mitochondria
1st step of cascade?
humidification in upper airways -> 150mmHg
2nd step of cascade?
inhalation of dead space air reduces pressure of oxygen at alveoli -> 104mmHg
3rd step of cascade?
decline of PO2 across alveolar-capillary membrane -> 100mmHg
4th (a) step of cascade?
arterio-venous shunts (anatomical and physiological); approx 2-4mmHg (healthy), much healthier in uhealthy due to sigmoidal oxyhaemoglobin equilibrium reaction
4th (b) step of cascade?
mismatch of ventilation/perfusion ->96mmHg
5th step of cascade?
entry into systemic capillaries, respiring cells taking oxygen -> 40mmHg
Final step of cascade?
entry into mitochondria, loss through diffusive flux across capillary membrane, interstitial space, cell membrane and cytoplasm