{ "@context": "https://schema.org", "@type": "Organization", "name": "Brainscape", "url": "https://www.brainscape.com/", "logo": "https://www.brainscape.com/pks/images/cms/public-views/shared/Brainscape-logo-c4e172b280b4616f7fda.svg", "sameAs": [ "https://www.facebook.com/Brainscape", "https://x.com/brainscape", "https://www.linkedin.com/company/brainscape", "https://www.instagram.com/brainscape/", "https://www.tiktok.com/@brainscapeu", "https://www.pinterest.com/brainscape/", "https://www.youtube.com/@BrainscapeNY" ], "contactPoint": { "@type": "ContactPoint", "telephone": "(929) 334-4005", "contactType": "customer service", "availableLanguage": ["English"] }, "founder": { "@type": "Person", "name": "Andrew Cohen" }, "description": "Brainscape’s spaced repetition system is proven to DOUBLE learning results! Find, make, and study flashcards online or in our mobile app. Serious learners only.", "address": { "@type": "PostalAddress", "streetAddress": "159 W 25th St, Ste 517", "addressLocality": "New York", "addressRegion": "NY", "postalCode": "10001", "addressCountry": "USA" } }

Lecture 15 - Asthma Treatment Flashcards

(19 cards)

1
Q

Relievers?

A

provide relief from asthma symptoms, rapid onset short duration, smooth muscle relaxation, use as required e.g. asthma attack, exercise

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Preventers?

A

long-term control, anti-inflammatory to prevent attacks, taken daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

three types of bronchodilators?

A

inhaled beta-adrenergic agonists, anticholinergic agents, xanthine drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Beta-adrenergic agonist asthma management?

A

relaxation of smooth muscle (bronchodilation), reduced vascular permeability & edema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Beat-adrenergic agonist mechanism?

A

beta receptor -> AC -> ATP into cAMP -> PKA -> Ca activated K+ channel -> smooth muscle relaxation and inhibition of mediator release

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Alternate routes of administration?

A

oral, direct endotracheal instillation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Problems with toddler inhalation?

A

small tidal volume, small airways, rapid respiration, aversion to masks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Why use spacer?

A

More direct entry to the lung rather than stomach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Rapid action long duration b-adr asthma treatment?

A

Formoterol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Adverse effects of b-adr?

A

tremor, tolerance, hypokalemia, tachycardia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Prescription of LABA?

A

not as first base, only if all other therapies fail, does not relief

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Anticholinergic effects?

A

reduce mucus secretion, bronchoconstriction and inflammatory response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Ach drug?

A

Ipratropium Bromide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ipratropium Bromide characteristics?

A

slow onset, short duration, regular basis, low side effects (less tachyphylaxis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Ipratropium Bromide problem?

A

reduced mucociliary clearance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Xanthine drug effects?

A

non-selective inhibition of phosphodiesterase (bronchodilation), activate HDAC (anti-inflammatory), adenosine antagonist

17
Q

Effects of adenosine antagonism?

A

arrhythmia, CNS stimulation, gastric acid hypersecretion, diuresis

18
Q

Theophylline positive effects?

A

bronchodilation, increased diaphragm strength, increase mucociliary clearance, decreased dyspnea, CV performance, dec. pulmonary artery pressure, diuresis

19
Q

Theophylline side effects?

A

toxicity risk due to narrow therapeutic range - monitored by serum monitoring; nausea etc, seizure, hyperglycaemia