Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Bisc 414 > Lecture 13 > Flashcards

Lecture 13 Flashcards

1
Q

Hematopoietin Family

A

Receptor Features: comprised of 1 to 3 subunits
- Subunit expression used to regulate activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

IL-2 Receptor Subuinits (g-sharing)

A
  1. a-subunit
    • confers ligand specificity; NO transduction
  2. bg-subunit
    • weak binding/ signal transduction
  3. abg-subunit
    • physiologically active
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

a-subunit

A

Expressed in activated T-Cells; expressed in activated B-Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

b-chain bearing

A

Low-affinity receptors: NO signal transduction (HSC)
- IL-3, IL-5, GM-CSF
High-affinity receptors: YES signal transduction (Myeloid Precursor)
- B-subunit

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Interferon Family

A

Interferes with viral growth; inhibits proliferation and survival of viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Interferon-a (Made by multiple cell types)

A
  1. Induces ribonucleases (degrades RNA)
  2. Inhibits protein synthesis (translation)
  3. Destroys virally infected cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Interferon-b (made by activated mac/DC and virus-infected cells)

A
  1. Induces ribonucleases
  2. Inhibits protein synthesis
  3. Destorys virally-infected cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Interferon-g (made by NK cells and activated T-Cells)

A
  1. Drives TH to TH1 (TC development_
  2. Activates Macs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Interferon-l

A

Upregulate anti-viral genes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Protein Kinase R

A
  1. Activated by dsRNA
  2. Phosphorylates eIF2a (phosphorylation elongation)
  3. Blocks initiation of translation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

2’,5’-oligoA Synthetase

A
  1. Activated by dsRNA
  2. Activates latent ribonucleases
  3. Degrades viral mRNA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mx Proteins

A
  1. Inhibits viral transcription
  2. Detect nucleocapsid proteins
  3. Prevents virus assembly
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tumor Necrosis Factor Family

A

Not mainly about tumor necrosis
1. Regulates development and homeostasis
2. Signaling in a variety of tissues

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Tumor Necrosis Factor Family (TNF)

A
  1. Can be soluble or membrane-bound
  2. Receptors assemble into trimers
    -homotrimers
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

TNF-a

A

Macrophage
1. Pro-inflammatory
2. Anti-tumor (apoptosis)
3. Pro-survival

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Lymphotoxin-a

A

Lymphocytes
1. Immune activation
2. MHC expression
3. Increased adhesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Lymphotoxin-b

A

Lymphocyte differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

BAFF

A

B-Cell development and homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

APRIL

A

B-Cell development and homeostasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

CD40L

A

T-Cell Surface
1. B-Cell differentiation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

FasL (CD95L)

A

TC Cell
1. Induces apoptosis

22
Q

Signaling

A
  1. TNFs can be soluble or membrane-bound
  2. TACE can liberate soluble TNFa
23
Q

Signaling

A
  1. TNFa can bind to TNFR1 or TNFR2
24
Q

Caspases

25
Kinases
Cell activation/ proliferation
26
TNF Binding
Induces receptor trimerization
27
Receptor Trimer
Alters binding within the cytoplasmic domain
28
TNF-R1
1. Binds both TNF-a and TNF-b 2. Has a cytoplasmic death domain 3. Binding either promotes apoptosis or survival
29
HeLa Cells
1. Expresses Fas on their plasma membrane 2. Treated with FasL 3. Cells undergo apoptosis
30
HeLa Cells (2)
1. Nuclear Condensation 2. Cell Rounding 3. Membrane Blebbing - packets of cellular material - Plasma membrane keeps its integrity
31
FasL-induced Apoptotic Pathway
1. FasL binding trimerizes Fas receptors 2. Cytoplasmic death domains organize 3. Trimerized death domains bind FADD 4. DED on FADD binds to pro-capase-8
32
FasL-induced Apoptotic Pathway (2)
1. Pro-caspase-8 clustering cleaves/ activates capase-8 2. Caspase-8 initates the apoptotic cascade
33
Interleukin-17 Family
1. Functions primarily as homodimers 2. Associated with innate/inflammatory responses
33
Interleukin-17 Family
1. Functions primarily as homodimers 2. Associated with innate/inflammatory responses 3. Secreted by TH17 cells 4. Interface between innate and adaptive immune systems
34
IL-17
Directs TH17 cell development
35
IL-17A
TH17 and NK Cells 1. Pro-inflammatory cytokine release
36
Chemokine Family
1. signal through G-Protein Coupled Receptors 2. Induce chemotaxis by establishing a concentration gradient
37
CXCL
CXCR
38
CCL
CCR
39
XCL OR (CL)
XCR OR CR
40
CX3CL
CX3CR
41
Rho- family of small GTPases
1. Directs the actin cytoskeleton 2. Pivotal in cell motility
42
Activated Rac
Lamellipodia Formation - Protrusive; - Membrane Periphery - Orthogonal Arrays
43
Activated Cdc42
Filopodia Formation - Protrusive - Membrane Periphery - Bundled Filaments
44
Activated Rho
Stress Fiber Formation - Contractive - Cell Interior - Bundled Filaments
45
Interleukin-1 Family
1. Early Inflammatory Response 2. Decoy Receptors: Inhibits IL-1 signal
46
Hematopoietin Family (Class I Cytokine)
1. Hematopoietic Development 2. B- and T- Cell Differentiation 3. Receptor subunit expression
47
Interferon Family (Class II Cytokine)
Anti-viral Response
48
Tumor Necrosis Factor Family
1. Receptor trimerization 2. Apoptosis (or survival)
49
Interleukin-17 Family
TH17 signaling for an inflammatory response
50
Chemokines
1. Extravasation 2. Cell Migration

Bisc 414 (21 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions