Lecture 129 Flashcards
MCTD is defined by
patients exhibit clinical findings that overlap more than one connective tissue disease
What serological finding is found in most MCTD patients?
ANA positive
Clinical criteria for MCTD
- Swollen hands or fingers
- Synovitis
- Myositis
- Raynaud’s
- Acrosclerosis
What is the peak age range for polymyositis/dermatomyositis?
40-60 years of age
What region of the body is typically spared in polymyositis?
No facial muslce involvement
Classic presentation of polymyositis
Bilateral proximal muscle weakness (legs before upper extremities)
Patients with polymyositis can have ____ due to involvement of striated muscles in the ____
dysphagia, esophagus
What is the characteristic feature of dermatomyositis?
Heliotrope malar rash (dark red)
Where is erythema often present in patients with dermatomyositis?
Face, shoulders, upper chest, and back
Gottron papules are seen in what condition?
What do they look like?
Dermatomyositis
Red/purple papules over knuckles and extensor surfaces
Patients with dermatomyositis are at a higher risk for ____
Malignancy
What syndrome involves a subset of patients with both polymyositis and dermatomyositis, plus SLE-like arthritis?
Antisynthetase syndrome
What condition displays anti-Jo-1 autoantibodies?
Antisynthetase syndrome (PM/DM)
What condition are anti-Mi-2 autoantibodies specific for?
Dermatomyositis
What condition are anti-SRP autoantibodies associated with?
Polymyositis
Anti-115/140 autoantibodies indicate an increased risk for:
malignancy associated myositis
What serological criteria is used to diagnose MCTD?
High-titer anti-RNP
What is the key difference between MCTD and overlap syndromes?
Overlap syndromes do not have anti-RNP antibodies
Recurrent oral and genital ulcers plus uveitis is a classic presentation of:
Behcet’s disease
Behcet’s disease is most common in indivudals from ____
the Middle East and Asia
What HLA is associated with Behcet’s disease?
HLA-B51/B5
What treatment is used for severe or refractory Behcet’s disease?
TNF-alpha antagonists
Pharmacological agents used for Behcet’s disease:
Corticosteroids, colchicine, immunosuppressants
Fibromyalgia requires widespread MSK pain across ____ or more regions of the body
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