Lecture 12 Flashcards
__ is needed for the formation of additional synaptic connections
gene expression
late phase effects are thought to be initiated by __ which activates a transcription factor (i.e. __) which stimulates the expression of other proteins ultimately leading to __
protein kinase A; CREB; the generation of new synaptic contacts
what happens to the EPSPs when you add an inhibitory of protein synthesis?
you see short-term potentiation instead, it goes back to normal in a matter of hours
protein synthesis does not affect LTP in __
early stages
T/F: you can’t get new memories (learning, synaptic plasticity) without new neurons
FALSE
LTP is specific to __: just because one synapse is __ doesn’t mean it will have an effect on nearby synapses.
HOWEVER LTP is also __: if one pathway is strongly stimulated and a nearby pathway is weakly (or strongly) stimulated, __
the synapse; strengthened; associative; both synapses will be strengthened
low frequency stimulation on just one synapse with nothing else happening nearby causes __
long-term depression
it is the __ that strengthens the synapse and leads to lasting changes in how signals are transferred between cells
coordinated activity between the presynaptic and postsynaptic elements
results of NMDA receptor knockout mice: (3)
less LTP in hippocampus
less LTD in hippocampus
slow learners in water maze
results of NMDA receptors mutants with increased conductance of channels: (3)
stronger LTP
fast learners in mazes
long-lasting memory
genetic engineering of NMDA receptors affects hippocampal __
synaptic plasticity and learning
at a glutamatergic synapse: during low frequency stimulation, __ is being release from the presynaptic terminal and binding to __ receptors and activating them, giving a little __, also binding to __ receptors but not activating them (because __)
glutamate; AMPA; EPSP; NMDA; we don’t have a great enough EPSP to remove the magnesium)
at a glutamatergic synapse: at high frequency stimulation, there is a lot more __ being released from presynaptic terminal so there are more __ receptors being activated and thus more __ of the postsynaptic membrane (enough to __ allowing __ to flow into the cell)
glutamate; AMPA; depolarization of postsynaptic membrane; enough to remove the magnesium and activate NMDA receptors; calcium
the __ is the trigger for LTP
CALCIUM
we have seen experimentally that LTD perseverates in animals that have been exposed to __ __
ethanol perinatally
different levels of postsynaptic Ca can induce either _ or __
LTP or LTD
protein phosphatases basically act in the opposite way as __
protein kinases