Lecture 10 Innate host resistance

Question 1

Lack of resistance to a disease

Answer 1

susceptibility

Question 2

Ability to ward off disease

Answer 2

Immunity

Question 3

Recognizes foreign substances or microbes and acts to neutralize or destroy them

Answer 3

Immune system

Question 4

Defense agains any pathogen

Answer 4

innate immunity

Question 5

Immunity or resistance to a specific pathogen

Answer 5

Adaptive immunity

Question 6

Anitmicrobial secretions in mucus membranes

Answer 6

• Lysozyme
  
  • hydrolyzes bond connecting sugars in peptidoglycan
• Lactoferrin
  
  • secreted by activated macrophages and PMNs
  • sequesters iron from plasma
• Lactoperoxidase
  
  • Produces superoxide radicals

Question 7

Paneth cells produce ___ and ___

Answer 7

• lysozyme
• cryptins

Question 8

What is in tears

Answer 8

• Lysozyme
• Lactoferrin
• secretory IgA

Question 9

function of Antimicrobial peptides (AMPs)

Answer 9

Inhibit cell wall synthesis, form pores in the plasma membrane that cause lysis; and destroy DNA and RNA

Question 10

First class of cationic peptides

Answer 10

• linear, alpha-helical peptides that lack cysteine amino acid residues
  
  • e.g. cathelicidin

Question 11

second class of cationic peptides

Answer 11

• defensins, peptides that are open-ended, rich in arginine and cysteine, and disulfide linked
  
  • alpha and beta

Question 12

Third class of cationic peptides

Answer 12

• Larger peptides that are enriched for specific amino acids and exhibit regular structural repeats
  
  • e.g. histatin

Question 13

The complement system is composed of greater than ___ serum proteins

Answer 13

30

Question 14

what are the three major activities of complement system

Answer 14

• defending against bacterial infections
• bridging innate and adaptive immunity
• disposing of wastes

Question 15

what are the three major activation pathways fo the complement system

Answer 15

• Alternative
• Lectin
• Classical

Question 16

Which complement pathway is involved in nonspecific defenses against intravascular invasion by bacteria/fungi

Answer 16

Alternative Complement Pathway

Question 17

The alternative complement pathway begins with the activation of

Answer 17

C3

Question 18

The alternative complement pathway is dependent on

Answer 18

interaction of complement with repetitive structures on pathogens

Question 19

The Alternative complement pathway results in formation of

Answer 19

Membrane attack complex

Question 20

The classical complement pathway is usually dependent on

Answer 20

antigen-antibody interactions (thus it is part of acquired iimmunity and not as fast as other pathways)

Question 21

The lectin complement pathway begins with

Answer 21

activation of C3 and lectin binding

Question 22

The lectin complement pathway is dependent on

Answer 22

• interaction of host mannose binding protein (MBP) with pathogen surfaces
  
  • enhances phagocytosis