lect 9- Development of the Digestive System Flashcards
what is the cranial end of the primitive gut
oropharyngeal membrane
what is the caudal end of the primitive gut
cloacal membrane
what is the endoderm of the gut innervated by
external and enteric
what is another name for the intraembryonic cavity
coelom (body cavity) encased in mesoderm
what are organs that form between the mesentery and the posterior body wall and give some examples
retroperitoneal (kidney, aorta, IVC)
what are organs that form within mesenteries, but later fuse with the posterior body wall
secondarily retroperitoneal (pancreas, part of duodenum)
what are organs that are from the dorsal or ventral body wall that are inside the peritoneal cavity
intraperitoneal
when does the respiratory diverticulum (lung bud) appear on the ventral wall
at 4 weeks
what are symptoms of esophageal atresia and tracheoesophageal fistulas
cyanosis, coughing, gagging, choking with attempted feeding
how much does the stomach rotate in the CORONAL plane
45 degrees moving the pylorus anterior and to the right
what does the mesogastrium grow into
greater omentum
what does the lesser momentum connect
liver and duodenum to lesser curvature of stomach
what does the falciform ligament do
attaches the liver to the anterior body wall
where does most of the pancreas develop from
dorsal bud
what forms the inferior part of the head of the pancreas, including the uncinate process
ventral pancreatic bud
what is the total rotation of the gut
270 degrees
what week does the appendix form
11th
what is the twisting of the intestine
volvulus
what are symptoms of volvulus
bloody stools, constipation, biliary emesis
what is the ligament of treitz
suspensory ligament of duodenum that connects the duodenum to the diaphragm
what disorder is characterized by elevated AFP
omphalocele
what part of the gut does not rotate
Hindgut
what forms the urogenital sinus
allantois
what is the growth of the urorectum septum into the urogenital sinus directed by
SHH
what is the storm for the glands of the gut tube derived from
visceral mesoderm
what causes the different transcription factors to be expressed in different regions of the gut tube
RA gradient
what transcription factor specifies for the esophagus and stomach
SOX2
what transcription factor specifies for duodenum
PDX1
what transcription factor specifies for small intestine
CDXC
what transcription factor specifies for large intestine and rectum
CDXA
what do lesser momentum and falciform ligament form from
ventral mesogastrium (which is derived from mesoderm of septum transversum)
what is the most important molecular regulation of liver induction
FGF2
what occurs when the esophagus fails to lengthen sufficiently, and stomach is pulled into the esophageal hiatus through the diaphragm
congenital hiatal hernia
what is the most common characteristic of pyloric stenosis
projectile vomiting
what occurs when there is a persistence of a portion of the mesocolon
mobile cecum
what hernia occurs when there is entrapment of portions of the small intestine behind the mesocolon
retroiliac hernia
what occurs when the proximal jejunum and the intestine is short, with the portion distal to the lesion coiled around a mesenteric remnant
apple peel atresia
