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HEMATOLOGY 2 > LEC4 - SECONDARY HEMOSTASIS > Flashcards

LEC4 - SECONDARY HEMOSTASIS Flashcards

1
Q

Is a process whereby, on vessel injury, plasma proteins,
tissue factors, and calcium interact on the surface of
platelets to form a stable fibrin clot

A

coagulation

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2
Q

in coagulation, what are the components that interact on the surface of the platelets to form a stable fibrin clot

A

plasma proteins, tissue factors, and calcium

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3
Q

platelet interacts with __ to form a stable fibrin clot

A

fibrin

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4
Q

This is a mechanism consisting of a series of cascading
reactions involving development of enzymes from their
precursors (____) which will further be converted to an activated state

A

zymogen

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5
Q

the activated state of enzyme

A

serine proteases

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6
Q

involves the enzymatic activation of
series of plasma proteins in the coagulation system to form a
fibrin meshwork.

A

Secondary Hemostasis

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7
Q

who activates fibrinogen to fibrin

A

thrombin

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8
Q

Prothrombin is what factor

A

factor II

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9
Q

Factor III is known as

A

Tissue Thromboplastin

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10
Q

Factor IV is known as

A

Calcium Ions

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11
Q

it meds the coagulation factor to make the clot formed during the primary hemostasis strong

A

Secondary Hemostasis

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12
Q

Factor V name

A

Labile Factor, Proaccelerin

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13
Q

Factor VII name

A

Stable Factor, Proconvertin

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14
Q

Factor VIII name

A

Antihemophilic Factor

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15
Q

Factor IX name

A

christmas factor

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16
Q

Factor X name

A

stuart-prower factor

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17
Q

Factor XI name

A

Plasma Thromboplastin Antecedent

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18
Q

Factor XII name

A

Hageman Factor

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19
Q

factor xiii name

A

Fibrin Stabilizing Factor

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20
Q

which factor is important for us to activate the coagulation cascae - to power it up

A

factor IV - calcium ions

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21
Q
A
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22
Q

why do factor VI is omitted?

A

the function is the same with factor V

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23
Q

Antihemophilic Factor B/

A

Plasma
Thromboplastin
Component (PTC)

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24
Q

Hageman factor
(HF) belongs in intrinsic pathway, which group does iT belongs as well

A

contact group

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25
Q

Fibrin Stabilizing
factor (FSF is also known aS

A

Laki-Lorand factor
(LLF)
Fibrinase

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26
Q

Prekallikrein other name

A

Fletcher factor

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27
Q

High Molecular
Weight Kiinogen
(HMWK) other name

A

Fitzgerald factor,
Williams factor, Flaujeac
factor

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28
Q

Categories of Coagulation Factors

A
  1. Substrate
  2. Cofactors
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29
Q

Substrate examples

A

Fibrinogen (Factor I)

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30
Q

Classification of Coagulation Factors by
Hemostatic Function

A

Substrate
cofactors
enzymes

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31
Q

enzymes examples

A

Serine Protease Ia, Ixa, Xa,
XIa, Transaminase,
Factor XIIIa,
Prekallikrein

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31
Q

Cofactors examples

A

Factor V (Labile Factor), Factor
VIII:C (AHF)

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32
Q

labile factors such as factor V and VIII works as a _____ according to its classification by hemostatic function

A

cofactors

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33
Q

Classification of Coagulation Factors by
Physical Properties

A

contact group
Prothrombin Group/
Vitamin K Dependent G
Fibrinogen

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34
Q

Contact Group components

A

XI, XII, Prekallikrein,
HMWK

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35
Q

Prothrombin Group/
Vitamin K Dependent
Group componensT

A

X, IX, VII, II

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36
Q

Fibrinogen group memvres

A

I, V, VIII, XIII

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37
Q

this classification according to physical properties of coagulation factors are the most labile

A

fibrinogen group

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38
Q

Factor V and VIII _______ upon storage of
blood specimen

A

dEteriorate

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39
Q

Fibrinogen Group

*Increased in

A

pregnancy, inflammation, and use
of contraceptive drugs

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40
Q

Fibrinogen Group ACTS as a substrate for

A

plasmin

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41
Q

Prothrombin Group

Composed of Factor

A

II, VII, IX, X

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42
Q

the classification of coagulation factor that is Stable and remains well preserved in stored
plasma

A

Prothrombin Group

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43
Q

all of the factors in prothrombin group we have is synthesized in

A

liver

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44
Q

Contact Group Composed of Factor

A

XI, XII, Prekallikrein, HMWK

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45
Q

a classification of coag factors that is Moderately stable and not consumed during
coagulation

A

Contact Group

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46
Q

charge of contact factors

A

negatively causing the cells to repel

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47
Q

who will activate pre kallikarein to kallikrein

A

activaTed factor XII

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48
Q

can contact factors be absorbed by almuninum hydroxide and barium sufate

A

nope

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49
Q

can contact factors be consumed by clotting

A

no

50
Q

are contact factors k dependent

A

no

51
Q

whre ca we found contact factors

A

both plasma and serum

52
Q

PROTHROMBIN

can they be absorbed by aluminum hydroxide and barium sulfate?

A

yes

53
Q

are PROTHROMBIN k deoendednt

A

yes

54
Q

PROTHROMBIN

consumed in clotting?

A

no

55
Q

PROTHROMBIN where are they found

A

both plaSma and sertum

56
Q

FIBRINOGEN

consumed by AL30H/BAS04?

A

no

57
Q

FIBRINOGEN

k dependent?

A

no

58
Q

FIBRINOGEN

consumed in clottng?

A

yeS

59
Q

FIBRINOGEN

found in

A

plasma

60
Q

which pathway will actvate common pathway

A

extrinsic and intrinsic

61
Q

This protein stabilizes the
linkage between the fibrin
monomers of the blood
clot.

A

Factor XIII – Fibrin
Stabilizing
Factor

62
Q

It is present in the plasma,
platelets and apparently
synthesized by
megakaryocytes.
stabilizes the fibrin clot

A

Factor
XIII – Fibrin
Stabilizing
Factor

63
Q

HL of factor XIII

A

HL 150 hours

64
Q

factor XII HL

A

HL 48-70

65
Q

This factor is activated by contact with foreign surfaces, and initiates
the intrinsic system

A

Factor XII

66
Q

It is also involved in the activation of fibrinolysis.

A

Factor XII

67
Q

if the intrinsic pathway starts with factor XII who will activate them tho?

A

the vessel injury will expose collagen and activate XII

68
Q

serine protease beta or gamma globulin partly
consumed in clotting found in serum and plasma

A

FXI

69
Q

FXI HL

A

48-84

70
Q

group of factor X

A

prothrombin

71
Q

factor X

Pptd by ____ ammonium sulfate.

A

55%-65%

72
Q

which factor is Activated by the products of both extrinsic and
intrinsic

A

Factor X

73
Q

Factor X HL

A

48-52

74
Q

Essential component of the
intrinsic thromboplastin
generating system

A

Factor IX

75
Q

Factor IX HL

A

24 hrs

76
Q

Factor VIII SOURCE

A

Endothelium lining blood vessel and platelet

77
Q

activator of FACTOR VIII

A

Thrombin

78
Q

Actions of factor XIII

A

Works with Factor IX and calcium to
activate Factor X

79
Q

Factor VII is
activated by

A

tissue
thromboplastin (factor III )

80
Q

HL OF FACtOR VII

A

6 hours

81
Q

synthesized in the liver; unstable when stored in citrated
plasma

A

Factor V

82
Q

factor V HL

A

24 hours

83
Q

is an active form of calcium that is required for the
activation of thromboplastin and for conversion of
prothrombin

A

Factor IV

84
Q

Factor IV mpc

A

:8-l0 mg/dl

85
Q

tissue factor cofactor half life insoluble used to
designate the clot accelerating action of extract of tissue

A

FIII

86
Q

____is required for the conversion of
prothrombin to thrombin

A

Thromboplastin

87
Q

Proenzyme , precursor of thrombin

A

FII

88
Q

Vit k is impt for the production of prothrombin by the

A

liver

89
Q

FII HL

A

60

90
Q

the substrate for thrombin and precursor of fibrin.
function is to be converted into a soluble protein

A

Factor I

91
Q

hl of fibrinogen

A

100-150

92
Q

This is a plasma protein with a molecular weight of
approximately 85,000 daltons.

A

Prekallikrein– Fletcher Factor

93
Q

dysfibrinogenemia
hypofibrinogenemia

A

non functional
low

94
Q

which factor has the least hl

A

factor VII

95
Q

Prekallikrein– Fletcher Factor

It is partially adsorbed by ___ but not adsorbed
by _____.

A

barium sulfate; aluminium hydroxide

96
Q

Activator of factor xi in
conjuction with w/ HMW

A

Prekallikrein– Fletcher Factor

97
Q

Prekallikrein– Fletcher Factor HL

A

Half life 35

98
Q

activator of factor xi in effect w/ prekallikerin

A

High
Molecular Weight Kininogen – Fitzgerald Factor

99
Q

Activation occurs when a vessel is injured, exposing
the subendothelial basement membrane and collagen

A

Intrinsic Pathway

100
Q

ACTIONS OF THROMBIN

A

Converts fibrinogen to fibrin

Activates Factor XIII

Enhances the activity of Factors V & VIII:C

Induces platelet aggregation.

101
Q

Induces platelet activation and aggregation Induces

A

platelet activation and aggregation

102
Q

Procoagulant

ü Activates cofactor ___

A

VIII to VIIIa

103
Q

Procoagulant

Converts Factor

A

XIII to XIIIa

104
Q

Procoagulant

Via autocatalysis converts Prothrombin to ___

A

Thrombin

105
Q

Binds antithrombin to inhibit serine proteases

A

Coagulation Inhibitor

106
Q

Binds to thrombomodulin to activate protein C (inhibits Va &
VIIIa)

A

Coagulation Inhibitor

107
Q

2 happenings in Tissue Repair

A
  • Induces cellular chemotaxis
  • Stimulates proliferation of smooth muscle and endothelial
    cells.
108
Q

physiologic Inhibitors of Coagulation (Anticoagulants)

A

Protein C
Protein S
thrombomodulin
antithrombin III

109
Q

3 inhibitors of coagulation that is calcium depedent

A

C, S, Z

110
Q
  • gp that is produced by the liver and is a major
    inhibitor of blood coagulation
A

Protein C-

111
Q

This inactivates Factors
VIII:C and Va in the presence of cofactor Protein S.

A

Protein C

112
Q

a vitamin K dependent protein and also produced
by the liver. This functions to enhance binding of Protein C
to phospholipid surfaces and increase the rate of Factors Va
and VIIIa inactivation by Protein C.

A

Protein S

113
Q

the protein that will inactivate factor V and factor VIII

A

Protein C-

114
Q

inhibits thrombin and inactivates the
clotting cascade.

A

Thrombomodulin

115
Q

major inhibitor of Thrombin and Factor
Xa.

A

Antithrombin III

116
Q

inhibits thrombin; activity is enhanced by
heparin

A

Heparin cofactor

117
Q

forms complex with thrombin,
kallikrein, thus inhibiting their activities.

A

Alpha 2 Macroglobulin

118
Q

lipoprotein associated
inhibitor(LACI) that inhibits VIIa which is a tissue complex
factor.

A

Extrinsic
Pathway Inhibitor-

119
Q

inactivates Factor XIIa and plasma kallikrein,
Factor XIa and plasmin.

A

C1 inhibitor

120
Q

a slow reacting thrombin inhibitor which
inhhibits Factor XIa and Xa.

A

Alpha1 Antitrypsin

121
Q

inhibits Protein C. This is more
active when heparin is present.

A

Activated Protein C Inhibitor

122
Q

changes happens in labile factors onced deteriorated

A

pH

HEMATOLOGY 2 (18 decks)

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