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HEMATOLOGY 2 > LEC2 - principle of coagulation > Flashcards

LEC2 - principle of coagulation Flashcards

1
Q

Hemostasis

involves the interaction
of ___, ____, ___ and_____

A

vasoconstriction,
platelet adhesion and
aggregation and
coagulation enzymes

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2
Q
A
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3
Q

Hemostasis

a complex process that:

A

produces a clot to stop the bleeding
keeps the clot confined
dissolves the clot as the wound heal

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4
Q

Reduction in blood vessel diameter due to
smooth muscle constriction

A

Vasoconstriction

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5
Q

What happens during vasoconstriction

A
  1. reduces blood flow
  2. facilitate platelet adhesion
  3. enhance coagulation cascade
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6
Q

a reflexive and earliest response in vessel injury

A

vasoconstriction

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7
Q

the process of dissolving the clot is called as

A

fibrinolysis

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8
Q

The Key Cellular Elements of Hemostasis

A

Vascular Intima
Extravascular tissue factor
Platelets
Blood Coagulation Factors (Factor I-XIII) except factor VI
Fibrinolytic protein

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9
Q

The innermost lining of blood vessels is
a monolayer of metabolically active ___

A

endothelial cells

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10
Q

___ have the thickest wall of the vascular
system

A

Arteries

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11
Q

__ are larger and have more irregular lumen
than arteries

A

Veins

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12
Q

blood vessels 3 layers

A

Tunica Intima
Tunica media
Tunica adventitia

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13
Q

the layer of blood vessels that is known as the inner lining and composed of single layer of endothelial cell and also subendothelial layer of connective tissue

A

Tunica Intima

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14
Q

tunica intima is the layer of blood vessels that is known as the inner lining and composed of single layer of endothelial cell and also subendothelial layer of connective tissue called as ________

A

internal elastic lamina

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15
Q

a layer of blood vessel that is the middle, also short, composed
of smooth muscles and elastic tissues

A

Tunica media

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16
Q

outer most layer of blood
vessels

A

Tunica adventitia

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17
Q

Tunica adventitia is composed of

A

collagen and elastic fibers

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18
Q

the strongest among the blood vessel layer

A

tunica adventitia

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19
Q

The ___ provides the
interface between circulating blood and
the body tissues.

A

vascular intima

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20
Q

Vascular intima

The innermost lining of blood vessels is
a monolayer of metabolically active
____

A

endothelial cells

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21
Q

Role of Endothelial Cell

A

Immune response
Vascular permeability
Proliferation
Hemostasis

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22
Q

Role of Endothelial Cells in immune response

A

serves as the barrier preventing the transmigration of immune cells

regulates the expression of surface adhesion molecules

production of mediators thus will control the circulating wbs

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23
Q

Role of Endothelial Cells in Vascular permeability

A

capacity of the vessel wall that allows the
flow of the blood

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24
Q

it controls the movement of the small and large molecule from the blood

A

Vascular permeability

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25
Role of Endothelial Cells in proliferation
can promote hematopoietic stem cells & differentiation
26
Role of Endothelial Cells in Proliferation
maintain the survival and self-renewal of hematopoietic stem cells
27
_____ the tissues surrounding blood vessels involved in hemostasis when local vessel is injured
Extravascular Component
28
The extra-vascular ( tissues surrounding blood vessels) involved in hemostasis when local vessel is injured, through ___ and ____
swelling and inflammation
29
It plays a part in hemostasis by providing back pressure on the injured vessel through swelling and trapping of escaped blood
Extravascular
30
destruction or lysis of the fibrin during wound healing
Fibrinolysis
31
Role of Blood Vessels in Hemostasis
Contraction or VASOCONSTRICTION (narrowing) and Dilation or VASODILATION
32
Blood flows through the vascular system to and from all parts of the body. The vascular system consists of ___, ____, and ____
capillaries, arteries, and veins.
33
Responsible for micro circulation that links between arterial and venous circulation.
Capillaries
34
Thinnest walled and most numerous of blood vessels compose of basement membrane that is tightly anchored with collagen that offers support for microvascular unit.
Capillaries
35
Smaller blood vessels
Arterioles and Venules
36
Microscopic continuation of arteries giving off meta arterioles joining capillaries
Arterioles
37
: the microscopic size of veins connecting to capillaries
Venules
38
Is the process whereby on vessel injury Plasma protein, Tissue factors and Calcium interact on the surface of the platelets to form a Fibrin clot
Coagulation
39
Tissue factors is also known as
factor III
40
what's the difference of factor III to other factors?
we are not being deficient of factor III
41
very important in the activation of coagulation factors, without this there is no activation of coagulation factors or no clot formation.
calcium
42
Platelets provide a surface for the coagulation reaction, and interact with ____ to form a STABLE PLATELET-FIBRIN (FXIII) CLOT.
fibrin
43
The major role of the hemostatic system is to ______
maintain a complete balance of the body’s tendency toward CLOTTING and BLEEDING .
44
inhibits or slow down the process of platelet activation and aggregation
Prostacyclin
45
how will prostacyclin together with nitric oxide helps in normal blood flow
inactivates platelet by preventing it to adhere to endothelial cells as another platelet
46
role of Heparin sulfate
enhances the activity of anti- thrombin III or ATIII
47
role of anti-Thrombin III
will inactivate the thrombin
48
role of thrombin
activates the fibrinogen to become fibrin
49
this is the activated form of factor II or prothrombin
thrombin
50
anticoagulant in which are produce by the endothelial cell
Tissue factor pathway inhibitor
51
induces smooth muscle relaxation, vasodilation and inhibits the platelet activation
Nitric oxide-
52
also present in endothelial cells, act as normal anticoagulant
Thrombomodulin
53
what are the substances or the component that will suppress the hemostasis or the formation of clot in a normal blood flow
prostacyclin nitric oxide heparin sulfate tissue factor pathway inhibitor thrombomodulin
54
- formation of clot or thrombus formation
Coagulation
55
Poor clot formation
HYPOCOAGULATION
56
in HYPOCOAGULATION - there will be an excessive fibrinolysis which can lead to
bleeding
57
examples of Hypocoaguble disease
Hemophilia Acquired conditions such as Disseminated intravascular coagulation , Liver and Kidney diseases.
58
hemophilia A- ___ deficiency
factor VIII
59
hemophilia B- _deficiency
factor IX
60
hemophilia C- factor _____ deficiency
XI
61
Liver is involved in hypocoagulation disease because __
most of coagulation factors are synthesize in the liver.
62
 uncontrolled  production of thrombi
HYPERCOAGULATION
63
Other conditions are related to uncontrolled thrombosis are called
Hyper-coagulable state.
64
This is related to an appropriate formation of thrombi in the vascular vessels that occlude normal blood flow.
HYPERCOAGULATION
65
Thrombus is composed of ____, ___, ____ and _____ And the tendency mahihirapan magflow yung RBC. And will lead to Myocardial infarction, mild stroke and death.
platelets, WBC, RBCs, cholesterol.
66
seen in cases of Polycythemia vera (high risk of having this)
Uncontrolled thrombosis-
67

HEMATOLOGY 2 (18 decks)

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