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CLINICAL CHEMISTRY 2 > [LEC] Pancreatic Enzymes and Cardiac Markers > Flashcards

[LEC] Pancreatic Enzymes and Cardiac Markers Flashcards

1
Q

EC CODE OF AMYLASE

A

3.2.1.1

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2
Q

RECOMMENDED NAME OF AMY

A

ALPHA AMYLASE

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3
Q

ENZYME CLASSIFICATION OF AMY

A

HYDROLASE

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4
Q

EC CODE OF CHYMOTRYPSIN

A

3.4.21.1

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5
Q

RECOMMENDED NAME OF CHY

A

CHYMOTRYPSIN

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6
Q

ENZYME CLASSIFICATION OF CHY

A

HYDROLASE

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7
Q

EC CODE OF E1

A

3.4.21.36

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8
Q

RECOMMENDED NAME OF E1

A

ELASTASE 1

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9
Q

ENZYME CLASSIFICATION OF E1

A

HYDROLASE

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10
Q

EC CODE OF LPS

A

3.1.1.3

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11
Q

RECOMMENDED NAME OF LPS

A

TRIACYLGLYCEROL LIPASE

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12
Q

ENZYME CLASSIFICATION OF LPS

A

HYDROLASE

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13
Q

ENZYME RESPONSIBLE FOR THE BREAKDOWN OF STARCH AND GLYCOGEN

A

AMY

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14
Q

ACTIVATING SUBSTANCES OF AMY

A

CALCIUM
CHLORIDE

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15
Q

CALCIUM AND CHLORIDE ACTIVATE WHAT ENZYME

A

AMY

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16
Q

SMALLEST ENZYME

A

AMY
50k to 55k DALTONS

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17
Q

ENZYME NORMALLY PRESENT IN URINE

A

AMY
Readily filtered in the glomerulus

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18
Q

MAIN TISSUE SOURCE OF AMY

A

PANCREAS’ ACINAR CELLS
SALIVARY GLANDS

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19
Q

MINOR TISSUE SOURCES OF AMY

A

SKELETAL MUSCLE
SMALL INTESTINE
FALLOPIAN TUBES

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20
Q

ISOENZYMES OF AMY

A

S — PTYALIN
P — AMYLOPSIN

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21
Q

ISOENZYME IMMEDIATELY DEGRADED BY GASTRIC CONTENTS

A

S
PTYALIN

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22
Q

STARCH ISOENZYME OF AMY

A

PTYALIN

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23
Q

CHROMOSOME THAT CODES FOR PTYALIN

A

CHROMOSOME 1

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24
Q

ISOENZYME DERIVED FROM THE SALIVARY GLANDS

A

S
PTYALIN

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25
Q

3 FORMS OF THE PTYALIN ISOENZYME

A

S1
S2
S3

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26
Q

AMY ISOENZYME THAT MIGRATES THE FASTEST TO THE ANODE

A

S
PTYALIN

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27
Q

AMY ISOENZYME THAT IS INVOLVED IN POLYSACCHARIDE HYDROLYSIS

A

P
AMYLOPSIN

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28
Q

CHROMOSOME THAT CODES FOR THE AMYLOPSIN ISOENZYME

A

CHROMOSOME 1

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29
Q

3 FORMS OF THE AMYLOPSIN ISOENZYME

A

P1
P2
P3

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30
Q

MOST PREDOMINANT FORM OF AMYLOPSIN PRESENT IN ACUTE PANCREATITIS

A

P3

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31
Q

ISOENZYME PREDOMINANTLY PRESENT IN URINE

A

P
AMYLOPSIN

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32
Q

SLOWEST AMY ISOENZYME THAT MIGRATES TO THE ANODE

A

P
AMYLOPSIN

33
Q

CATHODAL AMY ISOENZYME

A

P
AMYLOPSIN

34
Q

AMY LEVELS IN BLOOD UNDER NORMAL CONDITIONS

A

LOW LEVELS

35
Q

ACTIVITY OF AMY TOTAL CONCENTRATION IN ACUTE PANCREATITIS

A

RISE — 2-12 HRS
PEAK 24 HRS
NORMAL — WITHIN 3-5 DAYS

36
Q

ENZYMES USED WITH AMY IN THE DIAGNOSIS OR MONITORING OF ACUTE PANCREATITIS

A

URINE AMU (INCREASE)
AMY-CREA RATIO
SERUM LIPASE
AMY QUANTITATION

37
Q

CLINICAL CONDITIONS WITH AN INCREASE OF AMY

A

ACUTE PANCREATITIS
SALIVARY GLAND INFLAMMATION

38
Q

PRONOUNCED ELEVATION OF AMY IS SEEN IN WHAT CLINICAL CONDITIONS

A

ACUTE PANCREATITIS
PANCREATIC PSEUDOCYST
MORPHINE USAGE

39
Q

AMOUNT OF INCREASE IN PTYALIN DUE TO MORPHINE ADMINISTRATION

A

UP TO 50X ULN

40
Q

MODERATE ELEVATION OF AMY IS SEEN IN WHAT CLINICAL CONDITIONS

A

COMPLEXING ITH IGG OR IGA

PANCREATIC CARCINOMA
MUMPS
CHOLECYSTISIS
SALIVARY GLAND INFLAMMATION
PERFORATED PEPTIC ULCER IONIZING RADIATION

41
Q

MAJOR TISSUE SOURCE OF LPS

42
Q

MINOR TISSUE SOURCES OF LPS

A

STOMACH
SMALL INTESTINE

43
Q

ENZYME THAT CATALYZES THE HYDROLYSIS OF FAT

44
Q

PRODUCTS OF FAT HYDROLYSIS/EMULSIFICATION

A

ALCOHOL
FATTY ACIDS

45
Q

ACTIVITY OF LPS IN ACUTE PANCREATITIS

A

RISE — 48 HRS
PEAK — 24 HRS
REMAINS ELEVATED — 5D TO 2WK

46
Q

ENZYME MORE SPECIFIC FOR ACUTE PANCREATITIS

A

LPS
MORE SPECIFIC THAN AMP

47
Q

LEVELS OF LPS IN CHRONIC PANCREATITIS

A

NO LPS
More tissue damage = Less enzyme production

48
Q

LOW LPS CONCENTRATION OR THE ABSENCE OF LPS CAN BE USED TO DETERMINE THESEVERITY OF WHAT CONDITION

A

CHRONIC PANCREATITIS

49
Q

ACTIVE FORMS OF TRY

A

TRYPSINOGEN 1
TRYPSINOGEN 2

50
Q

INACTIVE FORM OF TRY

51
Q

CATIONIC TRY ISOENZYME

52
Q

MAJOR TRY ISOENZYME IN SERUM

53
Q

PERCENTAGE OF TR1 IN MILD ACUTE PANCREATITIS

54
Q

PERCENTAGE OF TR1 IN SEVERE ACUTE PANCREATITIS

A

AS LOW AS 30%

55
Q

NORMAL RATIO OF TR1 AND TR2

56
Q

ANIONIC TRY ISOENZYME

57
Q

TR2 UNDERGOES AUTOCATALYSIS AT WHAT PH

A

NEUTRAL OR ALKALINE PH LEVELS

58
Q

AMOUNT OF TR2 EXCRETED IN THE URINE IN ACUTE PANCREATITIS

A

MORE THAN TR2

59
Q

STIMULUS THAT ACTIVATES ZYMOGEN

A

STIMULUS FROM THE VAGUS NERVE OR BY CHOLECYSTOKININ-PANCREOZYMIN

60
Q

CONVERTING ENZYME OF ZYMOGEN IN THE INTESTINAL TRACT

A

ENTEROKINASE

61
Q

MAJOR TISSUE SOURCE OF CHYMOTRYPSIN

A

PANCREAS’ ACINAR CELLS

62
Q

ISOENZYMES OF CHY

63
Q

ENZYME OF CHOICE FOR FECAL EXAMINATION

64
Q

ENZYME THAT IS MORE RESISTANT TO DEGRADATION

65
Q

[TRUE OR FALSE]
TRY IS MORE RESISTANT TO DEGRADATION THAN CHY

66
Q

CHY LEVELS INCREASE IN WHAT CLINICAL CONDITION

A

CHRONIC PANCREATIC INSUFFICIENCY

67
Q

ENZYME USED TO MONITOR PATIENTS WITH CHRONIC PANCREATIC INSUFFICIENCY

68
Q

REFERENCE VALUE FOR FECAL CHY

A

12 U/G STOOL

69
Q

MOST RELIABLE AND SENSITIVE ENZYME USED TO DETECT PANCREATIC INSUFFICIENCY

70
Q

3 FORMS OF TROPONIN

71
Q

PROTEIN USED TO BIND ACTIN FILAMENTS IN CARDIAC AND SKELETAL MUSCLES

72
Q

INCREASE OF THIS PROTEIN IS INDICATIVE OF ARDIAC INJURY

73
Q

PROTEIN RELEASED IN BLOODSTREAM AHEAD OF ENZYMES IN CASES OF CARDIAC INJURY

74
Q

PROTEIN WITH A LONGER ELEVATION COMPARED TO CK

75
Q

TROPONIN ACTIVITY IN AMI

A

RISE — 4-10HR
PEAK — 12-48HR
ELEVATED — 2-10D

76
Q

REFERENCE INTERVAL OF cTnI
(Cardiac Troponin and Troponin I)

A

<0.1 ng/mL (mg/L)

77
Q

OXYGEN BINDING HEME PROTEIN

78
Q

PROTEINS USED DIAGNOSE OR RULE OUT CARDIAC ARREST

A

MYOGLOBIN
TROPONIN

79
Q

MYOGLOBIN ACTIVITY IN AMI

A

RISE — 2-3HR
PEAK — 8-12HR

CLINICAL CHEMISTRY 2 (10 decks)

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