[LEC] Bilirubin Flashcards
1
Q
[TYPE OF BILIRUBIN]
B1
A
UNCONJUGATED
2
Q
[TYPE OF BILIRUBIN]
B2
A
CONJUGATED
3
Q
[TYPE OF BILIRUBIN]
INDIRECT
A
UNCONJUGATED
4
Q
[TYPE OF BILIRUBIN]
DIRECT
A
CONJUGATED
5
Q
[TYPE OF BILIRUBIN]
BILIPROTEIN
A
DELTA
6
Q
[TYPE OF BILIRUBIN]
WATER INSOLUBLE
NON POLAR
A
UNCONJUGATED
7
Q
[TYPE OF BILIRUBIN]
POLAR
WATER SOLUBLE
A
CONJUGATED
8
Q
[TYPE OF BILIRUBIN]
BOUND TO ALBUMIN
A
UNCONJUGATED
9
Q
[TYPE OF BILIRUBIN]
FREE STATE
A
CONJUGATED
10
Q
[TYPE OF BILIRUBIN]
COVALENTLY BOUND TO ALBUMIN
A
DELTA
11
Q
[TYPE OF BILIRUBIN]
SHORTER HALF LIFE
A
UNCONJUGATED
12
Q
[TYPE OF BILIRUBIN]
HALF LIFE LESS THAN 24H
A
CONJUGATED
13
Q
[TYPE OF BILIRUBIN]
HALF LIFE ABOUT 17-29 DAYS
A
DELTA
14
Q
[TYPE OF BILIRUBIN]
NOT FILTERED
A
UNCONJUGATED
DELTA
15
Q
[TYPE OF BILIRUBIN]
READILY FILTERED
APPEARS IN URINE
A
CONJUGATED
16
Q
[TYPE OF BILIRUBIN]
TRANS FORM
A
UNCONJUGATED
17
Q
[TYPE OF BILIRUBIN]
CIS FORM
A
CONJUGATED
18
Q
[TYPE OF BILIRUBIN]
CAN CROSS THE BBB
A
UNCONJUGATED
19
Q
[TYPE OF BILIRUBIN]
CANNOT CROSS THE BBB
A
CONJUGATED
20
Q
[TYPE OF BILIRUBIN]
REQUIRES ACCELERATOR
A
UNCONJUGATED
21
Q
[TYPE OF BILIRUBIN]
DIRECTLY REACTS WITH DIAZO REAGENT
A
CONJUGATED
22
Q
[TYPE OF BILIRUBIN]
HEMOBILIRUBIN
A
UNCONJUGATED
23
Q
[TYPE OF BILIRUBIN]
CHOLEBILIRUBIN
A
CONJUGATED
24
Q
[TYPE OF BILIRUBIN]
PREHEPATIC
A
UNCONJUGATED
25
[TYPE OF BILIRUBIN]
POST HEPATIC
CONJUGATED
26
YELLOW DISCOLORATION OF THE SKIN, EYES, AND MUCOUS MEMBRANES
ICTERUS
JAUNDICE
27
RESULTS FROM THE RETENTION OF BILIRUBIN
JAUNDICE
28
MILD TYPE OF JAUNDICE THAT OCCURS PRIOR TO LIVER METABOLISM
PRE HEPATIC JAUNDICE
29
PRE HEPATIC JAUNDICE RESULTS FROM WHAT CLINICAL CONDITIONS
HEMOLYTIC ANEMIA
INEFFECTIVE ERYTHROPOIESIS
30
RESULTS FROM THE BREAKDOWN OF HEMOGLOBIN FROM A LARGE HEMATOMA
PRE HEPATIC JAUNDICE
31
DUE TO DEFECTS IN BILIRUBIN METABOLISM AND TRANSPORT
HEPATIC JAUNDICE
32
DUE TO DISEASES RESULTING I]TO HEPATOCELLULAR INJURY
HEPATIC JAUNDICE
33
MOST COMMON CAUSE OF JAUNDICE
GILBERT SYNDROME
34
TYPE OF BILIRUBIN IN GILBERT’S SYNDROME
UNCONJUGATED
35
UDPGT LEVEL IN GILBERT SYNDROME
LOW
36
BILIRUBIN SERUM CONCENTRATION IN GILBERT’S SYNDROME
1.5-3 MG/DL
37
OFTEN MISTAKENED AS CHRONIC HEPATITIS
GILBERT’S SYNDROME
38
DIFFERENCES OF GILBERT’S SYNDROME AND CHRONIC HEPATITIS
(ANEMIA, BILIRUBIN, LIVER FUNCTION)
ANEMIA — NO GS; YES CH
BILIRUBIN — NO GS; YES CH
LIVER FUNCTION — YES GS; NO CH
39
TREATMENT FOR GILBERT’S SYNDROME
PHENOBARBITAL
40
TYPE OF BILIRUBIN IN C
UNCONJUGATED
41
BILIRUBIN SERUM CONCENTRATION IN CRIGGLER-NAJJAR SYNDROME TYPE I
> 20 MG/DL
42
UDPGT LEVELS IN CRIGGLER-NAJJAR SYNDROME TYPE I
ABSENT
43
DISEASE THAT MAY PROGRESS TO KERNICTERUS
CRIGGLER-NAJJAR SYNDROME TYPE I
44
ENCEPHALOPATHY RELATED TO INCREASED SERUM UNCONJUGATED BILIRUBIN THAT LEADS TO PERMANENT BRAIN DAMAGE
KERNICTERUS
45
TREATMENT OF CRIGGLER-NAJJAR SYNDROME TYPE I
LIVER TRANSPLANT
46
TYPE OF BILIRUBIN IN CRIGGLER-NAJJAR SYNDROME TYPE II
UNCONJUGATED
47
BILIRUBIN SERUM CONCENTRATION IN CRIGGLER-NAJJAR SYNDROME TYPE II
5-20 MG/DL
48
UDPGT LEVELS IN CRIGGLER-NAJJAR SYNDROME TYPE II
PARTIAL DEFICIENCY
49
LESS SEVERE THAN TYPE I CRIGGLER-NAJJAR SYNDROME
CRIGGLER-NAJJAR SYNDROME TYPE II
50
TREATMENT OF CRIGGLER-NAJJAR SYNDROME TYPE II
PHENOBARBITAL
51
FAMILIAL FORM OF UNCONJUGATED HYPERBILIRUBINEMIA
LUCEY-DRISCOLL SYNDROME
52
TYPE OF BILIRUBIN IN LUCEY-DRISCOLL SYNDROME
UNCONJUGATED
53
UDPGT LEVELS IN LUCEY-DRISCOLL SYNDROME
INHIBITED
54
CAUSED BY THE PRESENCE OF AN INHIBITOR ENZYME OF UDPGT
LUCEY-DRISCOLL SYNDROME
55
LASTS FOR THE FIRST 2-3 WEEKS OF LIFE
LUCEY-DRISCOLL SYNDROME
56
TREATMENT OF LUCEY-DRISCOLL SYNDROME
PHOTOTHERAPY
57
PRINCIPLE OF PHOTOTHERAPY
BILIRUBIN IS BROKEN DOWN BY LIGHT
58
RARE DISORDER CHARACTERIZED BY JAUNDICE WITH BOTH TYPES OF BILIRUBIN
DUBIN-JOHNSON SYNDROME
59
TYPE OF BILIRUBIN IN DUBIN-JOHNSON SYNDROME
PREDOMINANT — CONJUGATED
MINOR — UNCONJUGATED
60
HEREDITARY DEFECT IN THE TRANSPORTER GENE
DUBIN-JOHNSON SYNDROME
ROTOR SYNDROME
61
LIVER HAS A GREENISH BLACK APPEARANCE
DUBIN-JOHNSON SYNDROME
62
LIPOFUSCHIN LIKE PIGMENT THAT COLOR THE LIVER A GREENISH BLACK COLOR
MELANIN
63
TREATMENT OF DUBIN-JOHNSON SYNDROME
NONE
Patients have a normal life expectancy
64
SIMILAR TO DUBIN-JOHNSON SYNDROME BUT WITHOUT LIVER PIGMENTATION
ROTOR SYNDROME
65
TREATMENT OF ROTOR SYNDROME
NONE
DUE TO EXCELLENT PROGNOSIS
66
DISEASES WITH INCREASED CONJUGATED BILIRUBIN
DUBIN-JOHNSON SYNDROME
ROTOR SYNDROME
67
DISEASES WITH INCREASED UNCONJUGATED BILIRUBIN
GILBERT’S SYNDROME
CRIGGLER-NAJJAR SYNDROME TYPE 1&2
LUCEY-DRISCOLL SYNDROME
68
UDPGT IS LOW
GILBERT’S SYNDROME
69
UDPGT IS ABSENT
CRIGGLER -NAJJAR SYNDROME TYPE 1
70
UDPGT IS INHIBITED
CRIGGLER-NAJJAR SYNDROME 2
71
NEUROLOGIC SYNDROME CAUSED BY THE DEPOSITION OF BILIRUBIN IN THE BRAIN
KERNICTERUS
72
EARLY SYMPTOMS OF JAUNDICE OF THE NEWBORN
POOR FEEDING
LETHARGY
VOMITING
BACK ARCHING OF THE TRUNK
73
BACK ARCHING OF THE TRUNK
OPISTHOTONOS
74
TIME WINDOW FOR BABIES TO BE JAUNDICED
WITHIN A FEW DAYS OF BIRTH
75
SUBSTANCE IN BREASTMILK THAT INHIBITS BILIRUBIN CONJUGATION
NEFA
PREGNANEDIOL
76
INGESTION OF THIS DRUG PROMOTES AN INCREASE OF UNCONJUGATED BILIRUBIN
ASPIRIN
77
WAVELENGTH AT WHICH PHOTOTHERAPY IS PERFORMED
450 NM
78
RESULTS FROM THE MATERNAL-FETAL INCOMPATIBILITY OF THE RHESIS BLOOD FACTORS
HEMOLYTIC DISEASE OF THE NEWBORNS
79
AFFECTS BREASTFED NEWBORNS DUE TO ALPHA GLUCURONIDASE IN BREAST MEALK
BREASTMILK HYPERBILIRUBINEMIA
80
DISEASES CAUSED BY CONJUGATED HYPERBILIRUBINEMIAS
IDIOPATHIC NEONATAL HEPATITIS
BILIARY ATRESIA
81
CAUSED BY THE DECREASED DRAINAGE OF BILIRUBIN DUE TO BILE DUCT BLOCKAGE, CONSTRICTION, OR ABSENCE
BILIARY ATRESIA
82
JAUNDICE CAUSED BY BLOCKAGE (GALLSTONES OR TUMORS)
POST HEPATIC JAUNDICE
83
DISEASE CAUSED WHEN ABCDEG VIRUSES TARGET THE LIVER
HEPATIC VIRAL INFECTION
84
CLINICAL CONDITIONS RELATED TO HEPATIC VIRAL INFECTION
CYTOMEGALOVIRUS
EPSTEIN BARR VIRUS
HERPES SIMPLEX VIRUS
85
CAUSED BY THE ACITE INJURY OF THE HEPATOCYTES VIA INGESTION OF TOXIC DRUGS, ISCHEMIA, OR AN IMMUNOLOGICALLY MEDIATED INJURY
ACUTE HEPATITIS
86
RESULTS FROM THE ACCUMULATION OF FATS AS A CONSEQUENCE OF INSULIN RESISTANCE IN CASES OF DM
NON ALCOHOLIC FATTY LIVER DISEASE
NON ALCOHOLIC STEATOHEPATITIS
87
CHRONIC INFLAMMATION OF THE LIVER THAT PERSISTS FOR AT LEAST SIX MONTHS
WITH FIBROSIS AND NECRO-INFLAMMATORY ACTIVITY
CHRONIC HEPATITIS
88
RAPIDLY PROGRESSIVE FORM OF CHRONIC HEPATITIS
AUTOIMMUNE HEPATITS
89
DIFFUSED FIBROSIS WITH NODULAR REGENERATION
CIRRHOSIS
90
TREATED BY PHENOBARBITAL
CRIGGLER-NAJJAR TYPE 2
GILBERT SYNDROME
91
TREATED BY LIVER TRANSPLANT
CRIGGLER-NAJJAR SYNDROME TYPE 1
92
TREATED BY PHOTOTHERAPY
LUCEY-DRISCOLL SYNDROME
JAUNDICE OF THE NEWBORN
