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[LEC] Bilirubin Flashcards

1
Q

[TYPE OF BILIRUBIN]
B1

A

UNCONJUGATED

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2
Q

[TYPE OF BILIRUBIN]
B2

A

CONJUGATED

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3
Q

[TYPE OF BILIRUBIN]
INDIRECT

A

UNCONJUGATED

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4
Q

[TYPE OF BILIRUBIN]
DIRECT

A

CONJUGATED

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5
Q

[TYPE OF BILIRUBIN]
BILIPROTEIN

A

DELTA

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6
Q

[TYPE OF BILIRUBIN]
WATER INSOLUBLE
NON POLAR

A

UNCONJUGATED

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7
Q

[TYPE OF BILIRUBIN]
POLAR
WATER SOLUBLE

A

CONJUGATED

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8
Q

[TYPE OF BILIRUBIN]
BOUND TO ALBUMIN

A

UNCONJUGATED

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9
Q

[TYPE OF BILIRUBIN]
FREE STATE

A

CONJUGATED

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10
Q

[TYPE OF BILIRUBIN]
COVALENTLY BOUND TO ALBUMIN

A

DELTA

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11
Q

[TYPE OF BILIRUBIN]
SHORTER HALF LIFE

A

UNCONJUGATED

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12
Q

[TYPE OF BILIRUBIN]
HALF LIFE LESS THAN 24H

A

CONJUGATED

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13
Q

[TYPE OF BILIRUBIN]
HALF LIFE ABOUT 17-29 DAYS

A

DELTA

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14
Q

[TYPE OF BILIRUBIN]
NOT FILTERED

A

UNCONJUGATED
DELTA

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15
Q

[TYPE OF BILIRUBIN]
READILY FILTERED
APPEARS IN URINE

A

CONJUGATED

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16
Q

[TYPE OF BILIRUBIN]
TRANS FORM

A

UNCONJUGATED

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17
Q

[TYPE OF BILIRUBIN]
CIS FORM

A

CONJUGATED

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18
Q

[TYPE OF BILIRUBIN]
CAN CROSS THE BBB

A

UNCONJUGATED

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19
Q

[TYPE OF BILIRUBIN]
CANNOT CROSS THE BBB

A

CONJUGATED

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20
Q

[TYPE OF BILIRUBIN]
REQUIRES ACCELERATOR

A

UNCONJUGATED

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21
Q

[TYPE OF BILIRUBIN]
DIRECTLY REACTS WITH DIAZO REAGENT

A

CONJUGATED

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22
Q

[TYPE OF BILIRUBIN]
HEMOBILIRUBIN

A

UNCONJUGATED

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23
Q

[TYPE OF BILIRUBIN]
CHOLEBILIRUBIN

A

CONJUGATED

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24
Q

[TYPE OF BILIRUBIN]
PREHEPATIC

A

UNCONJUGATED

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25
Q

[TYPE OF BILIRUBIN]
POST HEPATIC

A

CONJUGATED

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26
Q

YELLOW DISCOLORATION OF THE SKIN, EYES, AND MUCOUS MEMBRANES

A

ICTERUS
JAUNDICE

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27
Q

RESULTS FROM THE RETENTION OF BILIRUBIN

A

JAUNDICE

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28
Q

MILD TYPE OF JAUNDICE THAT OCCURS PRIOR TO LIVER METABOLISM

A

PRE HEPATIC JAUNDICE

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29
Q

PRE HEPATIC JAUNDICE RESULTS FROM WHAT CLINICAL CONDITIONS

A

HEMOLYTIC ANEMIA
INEFFECTIVE ERYTHROPOIESIS

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30
Q

RESULTS FROM THE BREAKDOWN OF HEMOGLOBIN FROM A LARGE HEMATOMA

A

PRE HEPATIC JAUNDICE

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31
Q

DUE TO DEFECTS IN BILIRUBIN METABOLISM AND TRANSPORT

A

HEPATIC JAUNDICE

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32
Q

DUE TO DISEASES RESULTING I]TO HEPATOCELLULAR INJURY

A

HEPATIC JAUNDICE

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33
Q

MOST COMMON CAUSE OF JAUNDICE

A

GILBERT SYNDROME

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34
Q

TYPE OF BILIRUBIN IN GILBERT’S SYNDROME

A

UNCONJUGATED

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35
Q

UDPGT LEVEL IN GILBERT SYNDROME

A

LOW

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36
Q

BILIRUBIN SERUM CONCENTRATION IN GILBERT’S SYNDROME

A

1.5-3 MG/DL

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37
Q

OFTEN MISTAKENED AS CHRONIC HEPATITIS

A

GILBERT’S SYNDROME

38
Q

DIFFERENCES OF GILBERT’S SYNDROME AND CHRONIC HEPATITIS
(ANEMIA, BILIRUBIN, LIVER FUNCTION)

A

ANEMIA — NO GS; YES CH
BILIRUBIN — NO GS; YES CH
LIVER FUNCTION — YES GS; NO CH

39
Q

TREATMENT FOR GILBERT’S SYNDROME

A

PHENOBARBITAL

40
Q

TYPE OF BILIRUBIN IN C

A

UNCONJUGATED

41
Q

BILIRUBIN SERUM CONCENTRATION IN CRIGGLER-NAJJAR SYNDROME TYPE I

A

> 20 MG/DL

42
Q

UDPGT LEVELS IN CRIGGLER-NAJJAR SYNDROME TYPE I

43
Q

DISEASE THAT MAY PROGRESS TO KERNICTERUS

A

CRIGGLER-NAJJAR SYNDROME TYPE I

44
Q

ENCEPHALOPATHY RELATED TO INCREASED SERUM UNCONJUGATED BILIRUBIN THAT LEADS TO PERMANENT BRAIN DAMAGE

A

KERNICTERUS

45
Q

TREATMENT OF CRIGGLER-NAJJAR SYNDROME TYPE I

A

LIVER TRANSPLANT

46
Q

TYPE OF BILIRUBIN IN CRIGGLER-NAJJAR SYNDROME TYPE II

A

UNCONJUGATED

47
Q

BILIRUBIN SERUM CONCENTRATION IN CRIGGLER-NAJJAR SYNDROME TYPE II

A

5-20 MG/DL

48
Q

UDPGT LEVELS IN CRIGGLER-NAJJAR SYNDROME TYPE II

A

PARTIAL DEFICIENCY

49
Q

LESS SEVERE THAN TYPE I CRIGGLER-NAJJAR SYNDROME

A

CRIGGLER-NAJJAR SYNDROME TYPE II

50
Q

TREATMENT OF CRIGGLER-NAJJAR SYNDROME TYPE II

A

PHENOBARBITAL

51
Q

FAMILIAL FORM OF UNCONJUGATED HYPERBILIRUBINEMIA

A

LUCEY-DRISCOLL SYNDROME

52
Q

TYPE OF BILIRUBIN IN LUCEY-DRISCOLL SYNDROME

A

UNCONJUGATED

53
Q

UDPGT LEVELS IN LUCEY-DRISCOLL SYNDROME

54
Q

CAUSED BY THE PRESENCE OF AN INHIBITOR ENZYME OF UDPGT

A

LUCEY-DRISCOLL SYNDROME

55
Q

LASTS FOR THE FIRST 2-3 WEEKS OF LIFE

A

LUCEY-DRISCOLL SYNDROME

56
Q

TREATMENT OF LUCEY-DRISCOLL SYNDROME

A

PHOTOTHERAPY

57
Q

PRINCIPLE OF PHOTOTHERAPY

A

BILIRUBIN IS BROKEN DOWN BY LIGHT

58
Q

RARE DISORDER CHARACTERIZED BY JAUNDICE WITH BOTH TYPES OF BILIRUBIN

A

DUBIN-JOHNSON SYNDROME

59
Q

TYPE OF BILIRUBIN IN DUBIN-JOHNSON SYNDROME

A

PREDOMINANT — CONJUGATED
MINOR — UNCONJUGATED

60
Q

HEREDITARY DEFECT IN THE TRANSPORTER GENE

A

DUBIN-JOHNSON SYNDROME
ROTOR SYNDROME

61
Q

LIVER HAS A GREENISH BLACK APPEARANCE

A

DUBIN-JOHNSON SYNDROME

62
Q

LIPOFUSCHIN LIKE PIGMENT THAT COLOR THE LIVER A GREENISH BLACK COLOR

63
Q

TREATMENT OF DUBIN-JOHNSON SYNDROME

A

NONE
Patients have a normal life expectancy

64
Q

SIMILAR TO DUBIN-JOHNSON SYNDROME BUT WITHOUT LIVER PIGMENTATION

A

ROTOR SYNDROME

65
Q

TREATMENT OF ROTOR SYNDROME

A

NONE
DUE TO EXCELLENT PROGNOSIS

66
Q

DISEASES WITH INCREASED CONJUGATED BILIRUBIN

A

DUBIN-JOHNSON SYNDROME
ROTOR SYNDROME

67
Q

DISEASES WITH INCREASED UNCONJUGATED BILIRUBIN

A

GILBERT’S SYNDROME
CRIGGLER-NAJJAR SYNDROME TYPE 1&2
LUCEY-DRISCOLL SYNDROME

68
Q

UDPGT IS LOW

A

GILBERT’S SYNDROME

69
Q

UDPGT IS ABSENT

A

CRIGGLER -NAJJAR SYNDROME TYPE 1

70
Q

UDPGT IS INHIBITED

A

CRIGGLER-NAJJAR SYNDROME 2

71
Q

NEUROLOGIC SYNDROME CAUSED BY THE DEPOSITION OF BILIRUBIN IN THE BRAIN

A

KERNICTERUS

72
Q

EARLY SYMPTOMS OF JAUNDICE OF THE NEWBORN

A

POOR FEEDING
LETHARGY
VOMITING
BACK ARCHING OF THE TRUNK

73
Q

BACK ARCHING OF THE TRUNK

A

OPISTHOTONOS

74
Q

TIME WINDOW FOR BABIES TO BE JAUNDICED

A

WITHIN A FEW DAYS OF BIRTH

75
Q

SUBSTANCE IN BREASTMILK THAT INHIBITS BILIRUBIN CONJUGATION

A

NEFA
PREGNANEDIOL

76
Q

INGESTION OF THIS DRUG PROMOTES AN INCREASE OF UNCONJUGATED BILIRUBIN

77
Q

WAVELENGTH AT WHICH PHOTOTHERAPY IS PERFORMED

78
Q

RESULTS FROM THE MATERNAL-FETAL INCOMPATIBILITY OF THE RHESIS BLOOD FACTORS

A

HEMOLYTIC DISEASE OF THE NEWBORNS

79
Q

AFFECTS BREASTFED NEWBORNS DUE TO ALPHA GLUCURONIDASE IN BREAST MEALK

A

BREASTMILK HYPERBILIRUBINEMIA

80
Q

DISEASES CAUSED BY CONJUGATED HYPERBILIRUBINEMIAS

A

IDIOPATHIC NEONATAL HEPATITIS
BILIARY ATRESIA

81
Q

CAUSED BY THE DECREASED DRAINAGE OF BILIRUBIN DUE TO BILE DUCT BLOCKAGE, CONSTRICTION, OR ABSENCE

A

BILIARY ATRESIA

82
Q

JAUNDICE CAUSED BY BLOCKAGE (GALLSTONES OR TUMORS)

A

POST HEPATIC JAUNDICE

83
Q

DISEASE CAUSED WHEN ABCDEG VIRUSES TARGET THE LIVER

A

HEPATIC VIRAL INFECTION

84
Q

CLINICAL CONDITIONS RELATED TO HEPATIC VIRAL INFECTION

A

CYTOMEGALOVIRUS
EPSTEIN BARR VIRUS
HERPES SIMPLEX VIRUS

85
Q

CAUSED BY THE ACITE INJURY OF THE HEPATOCYTES VIA INGESTION OF TOXIC DRUGS, ISCHEMIA, OR AN IMMUNOLOGICALLY MEDIATED INJURY

A

ACUTE HEPATITIS

86
Q

RESULTS FROM THE ACCUMULATION OF FATS AS A CONSEQUENCE OF INSULIN RESISTANCE IN CASES OF DM

A

NON ALCOHOLIC FATTY LIVER DISEASE
NON ALCOHOLIC STEATOHEPATITIS

87
Q

CHRONIC INFLAMMATION OF THE LIVER THAT PERSISTS FOR AT LEAST SIX MONTHS

WITH FIBROSIS AND NECRO-INFLAMMATORY ACTIVITY

A

CHRONIC HEPATITIS

88
Q

RAPIDLY PROGRESSIVE FORM OF CHRONIC HEPATITIS

A

AUTOIMMUNE HEPATITS

89
Q

DIFFUSED FIBROSIS WITH NODULAR REGENERATION

90
Q

TREATED BY PHENOBARBITAL

A

CRIGGLER-NAJJAR TYPE 2
GILBERT SYNDROME

91
Q

TREATED BY LIVER TRANSPLANT

A

CRIGGLER-NAJJAR SYNDROME TYPE 1

92
Q

TREATED BY PHOTOTHERAPY

A

LUCEY-DRISCOLL SYNDROME
JAUNDICE OF THE NEWBORN

CLINICAL CHEMISTRY 2 (10 decks)

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