lec 4 prenatal lower limb development Flashcards

1
Q

when do lower limb buds appear

A

week 4

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2
Q

when do lower buds become flattened and project at 90degree angle

A

week 5

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3
Q

when do knees point laterally

legs and feet rotated internally

A

week 6

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4
Q

when does free end of each lower limb turn 90 degrees medially

A

week 7
knees now point cranially/superiorly
soles of feet face each other

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5
Q

what happens in week 8

A

foot inhabits an equinus-supinates poition

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6
Q

rotation 1

A

coronal to parasagittal

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7
Q

rotation 2

A

medially along long axis of lower limb

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8
Q

lateral plate mesoderm destined to become

A

ligaments, bones, tendons, dermis

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9
Q

when is clearly defined footplate formed

A

week 5

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10
Q

when do toe rays become visible in foot plate

A

week 6

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11
Q

when do digits become webbed

A

week 7

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12
Q

ossification order

A
femur and tibia 
ilium
metatarsals and phalanges
ischium
pubis
tarsals
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13
Q

when do chrondrocytes form the 1st hyaline cartilage models and joints

A

week 6

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14
Q

posterior division of ventral rami supplies

A

developmentally dorsal muscles

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15
Q

anterior division of ventral rami supplies

A

developmentally ventral muscles

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16
Q

causes of limb abnormalities

A
genetic factors 
mutant genes
environmental factors-alc or drug during pregnancy
multifactoral inheritance 
stymied tissue interactions
mechanical effects
17
Q

polydactyly

A

duplication of digits

18
Q

congenital hip dysplasia

A

abnormal development of hip joint most likely from breech posture

19
Q

cutaneous syndactyly

A

webbing of digits

mesenchyme between prospective digits doesn’t undergo apoptosis