Lec 4

Question 1

Answer 1

Benign pedunculated adenomatous polyp and surrounding colonic mucosa

Question 2

Answer 2

Benign adenomatous polyp with normal surrounding colonic histology

Question 3

Answer 3

Adenocarcinoma of colon

Question 4

Answer 4

Adenocarcinoma of colon and adjacent normal colonic histology

Question 5

Answer 5

Lieomyoma in wall of uterus with surrounding normal myometrium

Question 6

Answer 6

Liemyosarcoma invading wall of myometrium

Question 7

Stem cells as the origin of cancer

Answer 7

-Skin: keratinocyte, sebaceous cells, hair, sweat gland
-Lung: Mucous cell, ciliated cell, neuroendocrine cell
-Colon: mucous cell, neuroendocrine cell
-Bone Marrow: red cell, granulocyte, platelet, lymphocyte, stromal cell

Question 8

Mutation Types

Answer 8

Gene
-replacement of one nucleotides or addition/deletion of nucleotide

Chromosome
-change in # or structure of chromosomes

Question 9

Oncogenes

Answer 9

-promotes abnormal cell growth/division when mutated

gain a function mutation on gene level

copy # gain or amplification on chromosome level

Question 10

Tumor suppressor genes

Answer 10

inhibit growth and division or induce genetic instability when mutated

loss of function (gene)

copy # loss or deletion (chromosome)

Question 11

Upstream vs Downstream

Answer 11

Question 12

Cancer in Men

Answer 12

Question 13

Answer 13

Bronchogenic lung cancer invading pulmonary parenchyma

Question 14

Cancer in Women

Answer 14

Question 15

Preneoplastic Predispositions

Answer 15

Question 16

Answer 16

Cirrhotic liver with secondary hepatocellular carcinoma

Question 17

Answer 17

Intestinal metaplasia and esophagus cancer at gastroesophageal junction

Question 18

Grading and Staging

Answer 18

Question 19

Answer 19

Abnormal Pap smear with severely dysplastic squamous mucosa cells

Question 20

Answer 20

Metastatic cancer to lung

Question 21

Answer 21

Metastatic cancer to liver