L/L

Question 1

Leukemias and Lymphomas

Answer 1

Pathogenic defect is a block in differentiation causing maturation arrest from acquired mutations in lineage- specific transcription factor genes

Question 2

80-85% are ___ in origin

Answer 2

B-cell

Question 3

Lymphomas present as ___

Answer 3

painless masses

Question 4

Leukemias present due to ___

Answer 4

marrow replacement
-anemia
-leukopenia
-thrombocytopenia

Question 5

Leukemias

Answer 5

2% of cancers
-specific cell markers and genetic abnormalities

Question 6

Acute Lymphoblastic Leukemia

Answer 6

70% of childhood leukemias
-mostly precursor B cell lymphoblasts in bone and marrow

Question 7

Answer 7

Lymphoblasts in blood

Question 8

Answer 8

Lymphoblasts in bone marrow

Question 9

Chronic Lymphocytic Leukemia

Answer 9

-30% of adult leukemias
-proliferation of mature lymphocytes mostly in blood
-10 yr survival
-SLL/CLL

Question 10

Answer 10

Small mature lymphocytes, but way too many in blood and bone marrow

Question 11

Acute Myeloblastic Leukemia

Answer 11

-mostly older pts
-WBC > 100k
-Karyotyping clinically predictive

Question 12

Chronic Myeloid Leukemia

Answer 12

-170k WBC
-Metamyelocytes/myelocytes/bands
-Chr T 9, 22
-Blast crisis termination

Question 13

Hodgkin’s Lymphoma

Answer 13

-Reed Sternberg Cell
-Germinal center B cell origin
-Spreads by continuity

Question 14

Answer 14

Reed Sternberg Cell

Question 15

Hodgkins Lymphoma Staging

Answer 15

1: single lymph node
2: two lymph nodes, same side
3: both sides of diaphragm +/- spleen
4: multiple/disseminated (A=no fever, B=fever)

Question 16

Answer 16

Hodgkins Lymphoma involving Liver

Question 17

Nodular Sclerosis

Answer 17

most common HL
-young ppl
-good prognosis

Question 18

Mixed cellularity

Answer 18

M > F, above 50
-disseminated with symps

Question 19

Lymphocyte Predominant

Answer 19

younger males
-5% of HL

Question 20

Answer 20

HL Mixed Cellularity

Question 21

Lymphoma Grades

Answer 21

-Indolent, Low grade (long survival, never cured)
-Aggressive, High grade (high death, curable)

Question 22

Answer 22

Follicular Lymphoma

Question 23

SLL vs CLL

Answer 23

in CLL bone marrow involvement exceeds lymph nodes, and in SLL it’s the reverse

Question 24

Answer 24

Diffuse Large B cell Lymphomas, 50% of lymphomas in adults