Lec 3

Question 1

Acute Inflammation, Chemical Mediators

Answer 1

Histamine, prostaglandins, from mast cells

Cytokines from Macs (IL1, TNF, IL6, chemokines)

Question 2

Acute Inflammation, Stages

Answer 2

-Vasodilatation
-Increased vascular permeability
-Edema
-Leukocyte (esp neuts) recruitment
-Rolling, pavementing, migrating
-Leukocyte activation
-Phagocytosis, killing / degradation

Question 3

Answer 3

Neutrophils

Question 4

Answer 4

Question 5

Chronic Inflammation

Answer 5

Persistent infection

Autoimmune disease

Prolonged exposure to toxin

Question 6

Chronic Inflammation, Histopathology

Answer 6

Macs, lymphocytes, plasma cells

Granulation tissue, angiogenesis

Scarring fibrosis

Question 7

Answer 7

Neutrophils in pulmonary alveolar airspaces, acute bronchopneumonia

Question 8

Answer 8

Interstitial fibrosis and chronic inflammatory cells (lymphocytes), interstitial pneumonia

Question 9

Answer 9

Chronic Inflammation (lymphocytes and plasma cells)

Question 10

Chronic Inf, Chemial Mediators

Answer 10

-Activated Macs (IL1, TNF, FGF)

-Activated lymphs (FGF, interferon)

Question 11

Answer 11

Tuberculous with granulomas

Question 12

Wound Healing

Answer 12

-Bleeding, clotting, fibrin matrix
-Macs secrete fibroblast growth factor (FGF)
-Fibroblasts make collagenase + remodel
-Angiogenesis granulation tissue
-Fibrous scarring, 1st and 2nd intention

Question 13

Growth factors in healing

Answer 13

stimulate the function of growth control genes

called proto-oncogenes because mutations in them lead to unrestrained cell proliferation characteristic of cancer (oncogenesis)

Question 14

Answer 14

Granulation tissue with proliferating capillaries (circled), and fibroblasts (arrowheads)