Lec 2

Question 1

Greek for corpse

Answer 1

Necros

Question 2

Life

Answer 2

characterized by active metabolism (chemical changes converting nutriment to energy and living tissue)

Question 3

Death

Answer 3

when biochemistry becomes just chemistry, and entropy prevails unchecked

Question 4

Coagulative

Answer 4

caused by Ischemia/Infarcts

Question 5

Liquifactive

Answer 5

Focal bacteria infections – abscesses

Question 6

Fibrinoid

Answer 6

AgAbC complexes, radiation

Question 7

Caseous

Answer 7

Tuberculosis

Question 8

Common Events in Cell Injury and Death from Diverse Causes

Answer 8

1. Mitochondrial membrane dysfunction
2. Plasma membrane dysfunction
3. Lysosomal membrane dysfunction

Question 9

Answer 9

Yellow - acute MI (necrosis)
Blue - old MI (fibrous scar = white)

Question 10

Answer 10

Left = normal heart muscle

Center = red dead myocardium

Right = acute inflammation neutrophils

Question 11

Apoptosis

Answer 11

When a cell is deprived of growth factors or its DNA or proteins are damaged beyond repair, the cell kills itself by activating enzymes that degrade its own DNA and constituent protein
-cleaned up by macrophages, no inflammation (no neutrophils) results

Question 12

Answer 12

Normal EM of myocardium mitochondria (M)

black dots = glycogen granules

Question 13

Answer 13

Reversible damage-glycogen depletion and swollen mitochondria

Question 14

Answer 14

Irreversible calcium deposition

Question 15

Answer 15

Fatty liver, yellow and swollen

Question 16

Answer 16

Acute fatty change
-accumulation of triglycerides in fatty liver (alcohol effects)

Question 17

Answer 17

Non lactating breast, lobules and ducts without acini

Question 18

Answer 18

Lactating breast with normal hyperplasia

Question 19

Answer 19

Normal esophagus squamous mucosa (blue)

intestinal metaplasia of lower esophagus (yellow)

adenocarcinoma (red)

Question 20

Answer 20

Squamous mucosa of esophagus - BLUE

Intestinal metaplasia - YELLOW