LEC 3 - Reproductive Drugs - Males

Question 1

What type of hormone are gonadotropins?

Answer 1

Glycoprotiens

Question 2

How do gonadotropins compare across species?

Answer 2

Identical alpha subunits

Different beta subunits

Question 3

What are the gonadotropins?

Answer 3

FSH

LH

CG

Question 4

What is the specific prostaglandin in reproduction?

Answer 4

PGF2alpha

Question 5

Where are the steroid reproducive hormones produced?

Answer 5

Throughout the reproductive tract

GOnads

Uterus/placenta

Hypothalamus

Question 6

What are the characteristics of the steroid reproductive hormones?

Answer 6

Short 1/2 lives

Long duration of action

Question 7

What is the characteristic of the GnRH cycle?

Answer 7

Plasma GnRH concentrations oscillate with peaks occurring every 60 to 90 minutes

Question 8

What does GnRH (from the hypothalamus) stimulate to happen in the anterior pituitary?

Answer 8

LH + FSH secretion

Question 9

What does LH from the anterior pituitary do?

Answer 9

Stimulate interstitial cells

Secrete testosterone

Question 10

What does FSH from the anterior pituitary do?

Answer 10

Stimulate seminiferious tubules

Sustentacular cells

Secrete Inhbin

Question 11

What does inhibit from the seminiferous tubules do?

Answer 11

Inhibits secetion of FSH

Question 12

What does testosterone from the interstitial cells do?

Answer 12

Inhibit GnRH secretion

Question 13

Intersitital cells aka

Answer 13

Leydig cells

Question 14

Sustentacular cells aka

Answer 14

Sertoli cells

Question 15

What are the two main uses for chorionic gonadotropin in males?

Answer 15

Correction of cryptorchidism

Determination of remnant testicualr tissue in castrated cats/dogs

Question 16

What are the hormones that control testicular descent?

Answer 16

Insulin-like GF 3

Anti-mullarian Hormone

Adrogens

Question 17

When an animal is given hCG where does it act?

Answer 17

Interstitial cells

Question 18

When does hCG have to be given inorder to aid in cryptorchisism?

Answer 18

during time of proper decent

first 8 weeks of life

Question 19

How is GnRH administered?

Answer 19

Digested in GI tract

So given IM

Question 20

How is human chorionic gonadotropin adminstered?

Answer 20

Digested in GI tract

IM adminstration

Question 21

How is hCG handled in the body?

Answer 21

Metabolized by the liver

To testes in males

To ovaries in females

Question 22

What are the adverse reactions to hCG?

Answer 22

Hypersensitivity reaction

(due to being from humans)

Question 23

How is hCG used to deteremine whether there is any remnant testicular tissue?

Answer 23

Draw blood

Give hCG/GnRH

Wait 60 to 90 minutes

Measure T = should be constant in castrated animal

Question 24

What is recommened for medical treatment in cases of benign prostatic hyperplasia in breeders?

Answer 24

Finasteride

– and –

Progestin

Question 25

Where does finasteride act in cases of benign prostatic hyperplasia?

Answer 25

5alpha - reductase

Question 26

Where do progestins act in cases of benign prostatic hyperplasia?

Answer 26

5alpha - dihydrotestosterone

Question 27

How is finasteride given?

Answer 27

PO

Question 28

How is finasteride handled by the body?

Answer 28

Metabolized by the liver 90% bound to plasma proteins

Question 29

What does finasteride have interactions with?

Answer 29

Anticholinergics

Question 30

What does finasteride do to hormone levels?

Answer 30

Lowers DHT but not testosterone Reduces prostatic diameter

Question 31

What are the two progestins?

Answer 31

Medroxyprogesterone acetate Megestrol acetate

Question 32

What is the progestin used in vet medicine?

Answer 32

Megastrol acetate

Question 33

How is megaestrol acetate handled by the body?

Answer 33

Absorbed in the GI tract Fully metabolized by the liver

Question 34

Whats improtant to note when handling progestins?

Answer 34

females need to be careful Increased risk of mammary/uterine cancers Fetal abnormalities