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MSK > Lec 11-12 Vasculitis > Flashcards

Lec 11-12 Vasculitis Flashcards

1
Q

What are clinical feat of small vessel vasculitis?

A

skin lesions universal

limited internal organ involvement

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2
Q

What are clinical feat of medium vessel vasculitis?

A
  • skin lesions less prominent

- varied but marked internal organ involvement

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3
Q

What are clinical feat of large vessel vasculitis?

A

minimal skin disease

prominent symptoms related to ischemia/ organ infarct

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4
Q

What is hypersensitivity vasculitis?

A

serum sickness
can be drug induced by penicillin, sulfa

have low grade fever , polyarthralgias/arthritis, maculopapular purpuric rash

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5
Q

What do you see in hep C vasculitis? 2 signs?

A

dependent palpable purpura
peripheral neuropathy
membranoporliferative glomerulonephritis

serum cryoglobulins + RF

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6
Q

What is henoch-schonlein purpura?

A

self limited small vessel vasculitis in kids; follows URI

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7
Q

What is classic triad of henoch shonlein purpura?

A
  • palpable purpura on buttocks/legs
  • srthralgias
  • GI –> ab pain, melena
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8
Q

What do you see when you biopsy the purpura of HSP?

A

IgA complex deposition = have IgA + C3 in vessel wall

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9
Q

What is bechet’s syndrome?

A

syndrome of recurrent mucosal ulcers in mouth and genitals

have uveitis, arthritis, cutaneous vasculitis

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10
Q

What is treatment for bechet?

A

colchicine

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11
Q

What is relapsing polychondritis?

A

episodic cartilaginous inflammation of both auricles; polyarthritis; saddle nose; malar rash

associates w/ SLE, IBD

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12
Q

WHat is treatment of small vessel vasculitis?

A

eradicate the antigen; NSAIDS; steroids; immunosuppression

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13
Q

What are three causes of infections medium vessel vasculitis?

A

Hep B
Hep C
HIV

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14
Q

What is buerger’s disease?

A

medium vessel vasculitis

heavy smoking –> intermittent claudication of extremity vessels

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15
Q

Who gets buerger disease?

A

male heavy smokers < 40

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16
Q

WHat is pathology of buergers?

A

PMN infiltration of vessel wall w/ thrombosis, intact elastic lamina

17
Q

What is pathology of polyarteritis nodosa?

A
  • associated with Hep B
  • focal lesions at bifurcations esp renal arteries
  • lungs spared
  • fibrinoid necrosis
  • non granulomatous
18
Q

What is treatment for PAN?

A

corticosteroids

cyclophosphamide

19
Q

What is microscopic polyangiitis?

A

small vessel necrotizing vasculitis involving lungs, kidney, skin, pauci-immune glomerulonephritis

20
Q

What type of ANCA associated with microscopic polyangiitis?

A

MPO-ANCA/p-anca = anti-myeloperoxidase

21
Q

What is treatment for microscopic polyangiitis?

A

cyclophosphamide

corticosteroids

22
Q

What is triad of wegeners?

A
  • focal necrotizing vasculitis
  • necrotizing granulomas in lung and upper airway
  • necrotizing glomerulonephritis
23
Q

What parts of body involved in wegener’s?

A
  • upper respiratory tract [differs from microscopic polyangiitis]
  • lower respirator tract
  • renal
24
Q

What are symptoms of churg strauss?

A

asthma, sinusitis, palpable purpura, peripheral neuropathy

can also involve heart, GI, kidneys [pauci-imune glomerulonephritis]

eosinophilia

25
Q

What type of ANCA associated with churg strauss?

A

MPO-ANCA/p-ANCA

26
Q

What is treatment for churg strauss and wegener?

A

cyclophospamide, corticosteroids

27
Q

What is takayasu arteritis?

A

pulseless disease = genulomatous thickening and narrowing of aoritc arch
high ESR
etiology unknown

28
Q

What is treatment for takayasu?

A

corticosteroids

29
Q

Who gets giant cell arteritis?

A

age > 50; females

30
Q

Who gets takayasu arteritis?

A

asian females

< 40 yo

31
Q

What are signs of giant cell arteritis?

A
  • unilateral headache
    jaw claudication
    can lead to irreversible blindness
    increased ESR
32
Q

What are some things that mimic vasculitis?

A
  • antiphospholipid syndrome
  • scleroderma
  • coumadin necrosis
  • scurvy
  • TTP

MSK (23 decks)

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