Learning And Memory Flashcards

1
Q

What is the definition of learning?

A

→ Acquisition of new information

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2
Q

What is the definition of memory?

A

→ Retention of learned information

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3
Q

What is declarative memory and what part of the brain is responsible for it?

A

→ Facts and events

→ Hippocampus

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4
Q

What is non declarative memory and what part of the brain is responsible for it?

A

→ Procedural memory (motor skills, habits)

→ Striatum

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5
Q

What 2 things come under classical conditioning?

A

→ Skeletal musculature (cerebellum)

→ Emotional responses (amygdala)

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6
Q

What is working memory?

A

→ Temporary storage that lasts seconds

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7
Q

What is short-term memory?

A

→ Facts and events are stored in short-term memory

→ Subset are converted to long-term memories

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8
Q

What is long-term memory?

A

→ Recalled months or years later

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9
Q

Where can sensory information go?

A

→ Long or short-term memory

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10
Q

What are the functions of the pre frontal cortex?

A

→ Self awareness

→ Capacity for planning and problem solving

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11
Q

Describe the delayed response task

A

→ place food in one of two wells
→ put a screen between the monkey and the wells

→ after a delay the screen is lifted
→ the monkey has to remember where the food is

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12
Q

What is associated with the visual cortex?

A

→ Lateral intraparietal cortex

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13
Q

What is an engram?

A

→ a collection of neurons that are responsible for the storage of a memory

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14
Q

What is the substrate where a memory is going to be stored?

A

→ A group of neurons that have reciprocal connections

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15
Q

Describe how an engram is formed

A

→ An external stimulus is presented
→ Activation of the cell assembly occurs

→ The combined activity creates a network that continues activation even after the stimulus has been removed
→This results in strengthening of certain connections between certain neurons
→ The strengthened connections of cell assembly contain the engram for the stimulus
→ even after learning partial stimuli lead to a whole representation of the stimulus

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16
Q

What is a Hebbian modification?

A

→ Strengthens the reciprocal connections between neurons that are activate at the same time

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17
Q

Where is the hippocampus located?

A

→ In the medial lobes

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18
Q

What kind of information comes to the hippocampus?

A

→ Sensory information

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19
Q

What does the hippocampus do with the information it receives?

A

→ Sensory information comes in

→ It is sent to the cortical association areas

20
Q

What kind of tissues are capable of forming engrams?

A

→ Any neuronal tissue

21
Q

What is the output pathway of the hippocampus?

A

→ the fornix

22
Q

Where does the fornix output to?

A

→ The thalamus and the hypothalamus

23
Q

What does the thalamus act as?

A

→ The post office sorting room for the brain

24
Q

What does the hippocampus feed back to and why is this important?

A

→ Feeds back to the cortical areas

→ Important for consolidation

25
Describe the pathway that sensory information takes
→ Sensory information goes to the cortical association areas → Parahippocampal and rhinal cortical areas → Hippocampus → Fornix → Hypothalamus and thalamus
26
What is amnesia?
→ Serious loss of memory and/or ability to learn
27
What are the 5 causes of amnesia?
→ Concussion → Chronic alcoholism → Encephalitis → Brain tumour → Stroke
28
What is retrograde amnesia?
→ Severe decrement in memories that they have before the trauma
29
What is anterograde amnesia?
→ Inability to form memories after the trauma
30
What happened to Henry Molaison?
→ The surgeon removed his medial temporal lobes | → lost the ability to make new long term memories
31
Why was Henry Molaison able to learn new motor skills?
→ Hippocampus was removed - declarative memory | → his non declarative memory - striatum - was still intact
32
How does a Morris water maze work?
→ Submerged platform in a wading pool → let mouse find the platform → make the water cloudy → let mouse find the platform again
33
When do place cells fire?
→ When animals are in certain areas after habituation
34
What are the 2 models of memory consolidation?
→ Standard model | → multiple trace model
35
What is the standard model of memory consolidation?
→ Information from neocortex areas associated with sensory systems are sent to the medial temporal lobe for processing → synaptic consolidation - within the hippocampus → post consolidation - the hippocampus is not necessary
36
What is the multiple trace model?
→ Hippocampal involvement is continued → multiple memory traces → Pathways can be continually modulated by continued experience
37
What is synaptic plasticity?
→ Biological process by which specific patterns of synaptic activity results in changes in synaptic strength
38
What does the model of distributed memory show?
→ Instead of three individual responses by three different neurons when you see 3 faces → there are changes in all 3 neurons when you see 1 face
39
Describe the trisynaptic circuit
Information flows from entorhinal cortex, via performant path to the dentate gyrus​ Mossy fibres originate from dentate gyrus and synapse upon pyramidal neurons in CA3 hippocampal region​ Axons from CA3 (Schaffer collaterals) synapse upon pyramidal neurons in CA1 hippocampal region​
40
What kind of stimulation is needed for long term potentiation?
→ High frequency rapid stimulation
41
What receptors are located on the CA1 neurons?
→ Glutamate | → NMDA and AMPA
42
Describe how long term potentiation works in CA1 neurons
→ AMPA receptors get stimulated → CA1 neurons gets depolarised ``` → NMDA receptors open → Ca2+ floods in → Calmodulin kinases are activated → AMPA responsivity is increased → more AMPA receptors added onto the post - synaptic membrane (CA1). → more responsive CA1 ```
43
What are the physiological changes in the dendritic spines after long term potentiation?
→ They swell because there are more receptors
44
What is the role of lateral intraparietal cortex?
response in delayed-saccade task​
45
When is the greatest firing in the delayed-saccade task?
delay period