Large Intestines Flashcards
Derived from endoderm except ectoderm derived distal anal canal
LI
LI develops during
4th gestational week
Right colon
Proximal 2/3 of transverse colon
Midgut
SMA
Distal 1/3 or transverse colon
Left colon descending, sigmoid and proximal rectum
Hindgut derived
IMA
Hindgut development
Joining of endoderm and ectoderm at dentate line and division of urogenital sinus and rectum by urorectal septum
Divides endo and ectoderm
Dentate line
Retroperitoneal
Right and left colon
Intraperitoneal
Transverse
Sigmoid
Layers of colon and rectum
Mucosa
Submucosa (similar to SI)
Inner circular muscle: coalesce in anal canal to form internal sphincter
Outer longituginal: taenia coli (cecum to sigmoid)
In rectum, cirumferential
Serosa: midlower rectum at peritoneal reflection
Contiguous and inferior to pelvic floor muscle (levator ani)
External sphincter (voluntary striated)
Attaches to presacral fascia posteriorly and fasia propria of mesorectum anteriorly
Retrosacral Waldeyer’s fascia
Separates rectum from prostate and seminal vesicle from vagina
Denonvillier’s fascia
Colon differentiated from SI by
appendices epiploicae (intraperitoneal fat pad) haustra (circumferential plicae in SI) bands of outer longitudinal (taenia coli)
Largest diameter
Thinnest wall
Inc risk of perforation
Cecum
Most redundant
Inc risk of volvulus
Sigmoid
Narrowest
Inc risk of obstruction
Sigmoid
Colonic and rectal mucosa epithelium
Simple columnar with intestinal glands (crypts of Lieberkuhn) secreting maltase sucrase deeper than in SI
2cm proximal to anal verge
dentate
2 cm proximal to anal verge, epithelium
changes to anal transition zone with mixture of columnar, cuboidal and squamous epithelium
Connects terminal branches of arteries supplying the colon
Marginal artery of Drummond
Watershed area
Junction of SMA and IMA
Vulnerable to ischemia
Splenic flexure
IMV drains to
All others run parallel to artery
spelnic vein
All others portal vein
Rectal submucosal hemorrhoidal plexus drains into
Superior
Middle
Inferior rectal vein
Sympathetic inn of large intestine
Thoracic splanchnic T10-T12 right
L1-L3 left colon and rectum
Parasympathetic inn of large intestine
Vagus right colon
S2-S4 left colon and rectum
Internal anal sphincter innervation
Sympa and para from pelvic plexus
External anal sphincter
Sensation and motor function
Inferior rectal nerve S2-S4 from pudendal
Lymph drainage of colon
Muscularis mucosa (epicolic bowel wall, paracolic, intermediate and main SMA and IMA) nodes
Rectum proximal to anal canal drains to IMA via mesorectum
Proximal anal canal drains to IMA or inguinal nodes
Distal anus drains to inguinal
Key component of radical resection for rectal cancer
Total mesorectal excision
Colon function
Water absortion 5L
Na, K, Cl absorption
Colonic bacteria: FA and NH4
Provide energy to colonocytectrom complex carbs
Short chain FA
Maintain tonic contraction at rest
Internal and external sphincter
Maintained by adequate sensory innervation
Compliance of rectum
Support from pevic floor muscle
Tone from IS and ES
Anal continence
As feces reach rectum, pelvic dloor and IS relax and ES contracts allowing feces to approach anus and anoderm
Rectoanal reflex
Colon lacks
MMEC but has low and high amplitude contraction from vagal stimulation
Normal epithelium mutating to dysplastic epithelium
APC
Early adenoma to intermediate adenoma
KRAS
Intermediate adenoma to late adenoma
DCC/DPC4/JV18?
Late adenoma to carcinoma
p53
Carcinoma to metastasis
Other changes
19, F
RLQ pain, febrile, hemodynamically stable
RLQ rebound tenderness and guarding
WBC= 13, HCG negative
CT: AA without perforation
OR: inflamed, attached to inflamed edematous ovary with purulence
Next step in management?
PID
Right oophorectomy and Appendectomy
Most common surgical emergency of abdomen
7% of population, W 2nd-4th decade
Occlusion of lumen
Acute appendicits
Pain upon palpation of left lower quadrant
Rovsing’s sign
Pain upon hip flexion
Psoas sign
Pain on Internal rotation of right leg
Obturator sign
Atypical symptoms of AA occur in
children
pregnant
elderly
Mild leukocytosis with or without left shift
AA
High sensitivity 95% preferred for dx of AA
CT Scan in most populations: enlarged enhancing appendix >6mm with or without fecalith, periappendiceal fat stranding and wall thickening
Beneficial dx in pregnant women and children
UTZ
AA tx
Gold standard
Lap or open appendectomy
If phlegmon, delay resection start antibiotic and perform interval appendectomy
15% negative appendectomy rate in spite of advances in imaging and technology
Used as landmark to find cecum and appendiceal base
Taenia coli
Divide appendiceal artery, resect appendix and invert and oversew base
Oblique incision
McBurney
Transverse incision
Rocky-Davis
Most common malignancy of appendix
Carcinoid tumor
Yellow mass <2cm at appendiceal tip in association with pain or obstruction
Arises from neuroendocrine enterochromaffin cells
90% in the appendix or distal ileum
Carcinoid tumor
Flushing Wheezing Edema Diarrhea Tricuspid insufficiency
carcinoid syndrome
Most conmonly found in the SI
Carcinoid
If tumor >2cm involves the appendiceal base or terminal ileum or is metastatic,
perform a right hemicolectomy
May alleviate symptoms of carcinoid syndrome
Ocreotide
15% of intestinal obstruction
May be caused by cancer, diverticulitis, volvulus, fecal impaction, postoperative adhesions, hernias or loss of peristalsis (pseudoobstruction)
Large bowel obstruction
Most common cause of LBO
Cancer
Pseudoobstruction
Ogilvie’s syndrome
Confirms LBO
CT
Abdominal radiograph in LBO
colonic distention
SI airfluid level
dilated colon without air in rectum - mechanical obstruction
air in rectum - pseudoobstruction
Tx LBO
Fluid resuscitation
Correct metabolic abnormality
NGT
Antibiotics if ischemic
First line in tx of LBO
surgery
resect and anastomose
Pseudoobstruction tx
NGT
Neostigmine to inc motility
Closed loop obstruction in at least two locations by twistint of bowel >/= 180 deg
Most common in sigmoid, cecum and transverse colon
Volvulus
Anteromedial folding of cecum on itself
Cecal bascule
Axial rotation of cecum around ileocolic vessel, resulting in twisting of mesentery
Cecal volvulus
Rf for volvulus
Redundant segment Megacolon Bedridden condition Chronic constipation Pregnancy
Involves rotation around mesosigmoid
Sigmoid volvulus
Involves rotation of ileum, cecum and ascending colon around mesentery and ileocolic vessel
Cecal volvulus
Volvulus may present with
sudden onset abdominal distention and pain
Confirms dx of volvulus
Abdominal radiograph: bent inner tube narrowing into a bird’s beak (sigmoid)
coffee bean - dilated cecum
Dilated cecum on radiograph
Coffee bean
does not resolve with NGT
Loops that are interposed between liver and diaphragm at risk for volvulus
Chilaiditi’s syndrome
First line for nonstrangulated sigmoid volvulus
endoscopic decompression (sigmoidoscopy, colonoscopy) placement of rectal tube
Passage of air and feces indicate
reduction of volvulus
Emergent surgery
cecal volvulus
cecopexy, right colectomy
Associated with high recurrence and reserved for selected cases
Cecostomy
First line for sigmoid volvulus but not for cecal
Endoscopic decompression
43, M Severe lower quadrant abdominal pain Denies prior nausea or vomiting Febrile but stable Slightly distended abdomen and tender B lower quadrant with guarding Leukocytosis
CT: diverticulosis of sigmoid with adjacent diverticular abscess on antimesenteric side of sigmoid colon
No pneumoperitoneum
Mx?
Admit
NPO
initiate IV antibiotics
Consider IR drainage if abscess is in amenable location
Most common colonic pathology
Diverticular disease