Esophagus Flashcards
Esophagus develops during gestation
4th week
Failure of separation of dorsal foregut from laryngotracheobronchial tree during development
TEF fistula
Failure of recanalization of tubular lumen
Esophageal atresia, web, stenosis
5-6cm
Extends from cricopharyngeus (C6) to thoracic inlet (T1)
Cervical esophagus
15cm From TO (T1) to esophagea hiatus of diaphragm (T10)
Thoracic esophagus
Short 5-6cm
Absent in patients with hiatal hernia or esophageal shortening from chronic inflammation
Abdominal esophagus
Cricopharyngeus (UES) innveration
recurrent laryngeal nerve
Functional zone not an anatomic structure
LES
Anatomic sites of esophageal narrowing
Most common sites of foreign body impaction
Aortic arch
left main stem Bronchus
Cricopharyngeus
Diaphragm
Esophageal wall layers
Mucosa
Submucosa
Muscularis
Esoohagus lacks this layer so healing is poor after insult
Serosa
Mucosa of esopahgus
Non keratinizing SSE
Muscularis layer is divided into
Outer longitudinal
Inner circular
Upper 1/3 of esophageal muscle
Lower 2/3
striated
smooth
Esophageal landmark by endoscopic distance from incisor
UES
Thoracic inlet
Aortic arch/LMB
LES/GEJ
UES 15cm
TI 18cm
Aortic arch/LMB 25cm
LES/GEJ 40cm
Upper 1/3 of esophagus blood supply
Inferior thyroid artery
Middle 1/3 esophagus blood supply
Descending thoracic aorta
Bronchial arteries
Lower 1/3 esophagus blood supply
Left gastric artery
Inferior phrenic artery
Parasympathetic inn to esophagus
Vagus nerve
Innervates cricopharyngeus and cervical region
recurrent laryngeal nerve
sympathetic fibers for the esophagus arise from
Cervical
Thoracic chain ganglia
Contains nonsegmented network of lymphatics
Submucosa
Upper 2/3 cephalad drain
Lower caudad
Site of cricopharyngeal weakness
Most common location to find pseudodiverticula or iatrogenic perforation
Killian’s triangle
35 y/o female
progressive heartburn, regurgitation of undigested food
barium swallow: bird beak tapering of distal esoph
manometry reveals:
Achalasia
Lack of peristalsis
Failure of LES relaxation
Strongest layer of esophagus
Primary importance for surgical repair
submucosa
Most common esophageal motility disorder
25-60 years equal distribution
Aperistalsis
Failure of LES relaxation during swallowing
Not a primary disorder but neural degeneration
Achalasia
Patients with achalasia present with
Progressive dysphagia to solids and liquids
Heartburn, chest paun
Regurgitation of undigested food
Techniques to ameliorate dysphagia by maintaining upright, keeping arms elevated over head, consuming liquid
Achalasia dx: finding
Barium swallow: bird beak with dilation if proximal segment
Dx mandatory to rule out obstructing mass or stricture
Esophagoscopy
Manometry in achalasia reveals
lack of peristalsis and failure LES relxation
resting LES pressure may be normal or high
UES pressure (resting)
50-70
UES pressure (bolus)
12-14
LES pressure (resting)
10-20
Medical management of achalasia
Nitrates
Ca ch blocker
Botox
Symptomatic improvement but recurrence is high and risk of perforation at 5% in achalasia repair
Pneumatic dilation
Definitive therapy: achalasia
Heller myotomy
Long standing severe achalasia
Dilated and non functional esophagus called
sigmoid esophagus
tx: esophagectomy
smooth muscle degeneration
LES failure
disordered peristalsis of distal esophagus
esophageal dysmotility in 80% women 40-50
sparing of:
Scleroderma
proximal striated
Scleroderma s and sx
severe reflux esophagitis
dysphagia
scleroderma (calcinosis, Raynaud, esophageal dysmo, sclerodactyly, skin change, telangiectasia, renal impairment, pulmonary HTN)
Scleroderma dx: finding
Barium: dilated esophagus with DISTAL NARROWING
Manometry: dysmotility, aperistalsis of distal esophagus with inc LES
Medical mx of scleroderma
Sx
H2 blocker
PPI
HOB elevation
severe with loss of function (fundoplicariob and gastroplasty)
Primary motility disorder
Disordered high amplitude motility
Substernal chest pain radiating to neck or upper ex
Dysphagia with solid and liquid
Diffuse esophageal spasm
DES dx: finding
Barium: corkscrew esophagus and segmentation
Manometry: frequent, high amp, simultaneous contraction (>/= 20% of 10 simultaneous waveform)
LES normal
DES medical mx
nitrate
Ca ch blocker
Botox
Most common primary motility disorder
Chest pain, dysphagia
Manometry: continuous, high amp (>/=2 SD above normal) peristalsis
Nutcracker esophagus
Tx:
Nitrate
Ca ch blocker
Sx: Heller if nonrefractory
Found at Killian’s triangle as a result of discoordination of UES relaxation and swallowing
Pharyngoesophageal
Zenker’s or Pulsion diverticulum
Either pulsion (motility disorder) or traction bec of extra esophageal disease such as cancer or granulomatous infection
Middle esophageal diverticula
Most commonly by motility d/o, achalasia
Associated with GERD
Within 10cm of GEJ
Epiphrenic diverticula
Regurgitation Halitosis Aspiration Chest pain Dysphagia Asymptomatic
Diverticulum
Diverticulum dx
Barium
Manometry and pH studies: motility disorder with reflux
Esophagoscopy to rule out mechanical obstruction
Sx for diverticula
Diverticulectomy with myotomy
Transoral stapled repair
Congenital incomplete recanalization but may be acquired
Trans or mucosal and submucosal
Asymptomatic but sometimes dysphagia with solid food
Associated with GERD or IDA (Plummer Vinson)
Esophageal web, ring
Ring at the GEJ due to GERD
Schatzki’s ring
Majority of paraesophageal hernias are
Type I sliding hiatal
Ulcer in sliding hiatal hernia
Lesser curve
Chronic blood loss but rarely with perforation
Cameron’s ulcer
Borchardt’s triad
Severe chest pain
Painful retching without emesis
Inability to pass NGT
incarcerated paraesophageal hernia
Incidenta on upper endoscopy or CT Bowel sounds on chest CXR air fluid level in chest Coiled intrathoracic NGT Barium swallow is dx
Esophageal hernia
Chest
Contains GEJ with or without fundus
No volvulus
Type I Sliding Hiatal
Abdomen
Contains fundus
Organoaxial volvulus
Type II rolling paraesophageal
Chest
Contains GEJ, fundus, body
Organoaxial and mesoaxial volvulus
Type III mixed paraesophageal
Chest
Contains GEJ, fundus abdominal organ
Organoaxial or mesoaxial volvulus
Type IV mixed paraesophageal
Chest pain and paraesophageal hernia is emergency surgery bec of
risk of incarceration or strangulation
Sliding hernia sx
Elective
Preferred surgery for chronic hernia
Transthoracic
Classic teaching for asymptomatic paraesophageal hernia
surgical repair for all
Paraesophageal hernia repairs must be
hernia reduction
Sac excision
Tension free closure of crural defect
Longitudinal mucosal tear near GEJ due to repeated retching and high intraluminal pressure
Common in alcoholics
Dx:
Mallory Weis tear
Endoscopy
Most common cause of esophageal perforation
iatrogenic
Spontaneous rupture of esophagus resulting from inc intraabdominal pressure against closed glottis during bouts of retching
Perforation by malignancy or infection (TB)
Elderly, delibiltated
Esophageal perforation
Severe chest and back pain Dyspnea Dull percussion at left chest Subcutaneous emphysems Tachycardia Hypotension Severe sepsis with instability
Esophageal perforation
Esoph perforation dx: finding
CXR: pneumomediastinum, subcutaneous emphysema, left hydropneumothorax, simple effusion
Demostrates leak in esophageal rupture
Gastograffin swallow
Localizes site of esophageal perforation
Esophagoscopy
Esophageal rupture tx
Broad spec antibiotics
NPO
Fluid resuscitation
Drainage of effusion decompression of pneumothorax
Esoph perforation operative therapy:
Irrigation and drainage of pleural cavity with primary repair of perforation
Reinforce with intercostal, pleural, pericardial flap
Alkali agents cause
liquefactive necrosis
Acids cause
coagulation necrosis
Caustic injury mx
Dx: flexible esophagoscopy
Assess and secure airway Do not neutralize agent Observe if asymptomatic Mildd admit NPO for 1-2 days Full thickness: NPO, TPN, antibiotic
Resect
Caustic injury complications
stricture
SCC
58 y/o,M
Hx of GERD
Endoscopy with biopsy: mild dysplasia
Ff up:
Endoscopic surveillance with biopsy every 2 years to monitor dysplasia
Premalignant condition by intestinal metaplasia
Primary risk factor: GERD (5-10)
Barett’s
If severe dysplasia is present perform
esophagectomy
Resected Barrett’s specimen with severe dysplasia have adenocarcinoma:
20-50%
SCC risk factors
Tobacco Alcohol Achalasia Alkali injury Plummer Vinson
Dx for SCC
Esophagoscopy with biopsy
staging: CT, PET, endoscopic uts
Most common esophageal malignancy
Adenocarcinoma
Adenocarcinoma rf
GERD
Barrett’sc
Benign lesions and motility disorders appear
smooth narrowing
Malignant lesions demonstrate
irregular apple core
appearance
Stage I and IIA sx
T3NO
Surgery +/- neoadjuvant
Stage IIB, III tx
chemoradiation (neoadjuvant) w/
surgery
stage IV tx
palliation: esophageal stent
Most common mortality and morbidity in postesophag
Postesohagectomy pneumonia
pulmo complication
Incision: laparotomy, neck
Anastomosis: neck
Transhiatal
Incision: laparotomy, right thoracotomy
anastomosis: chest
Ivor-Lewis
Incision: left thoracotomy
Anastosmosis: chest
Thoracoabdominal
Incision: laparotomy, right thoracotomy, neck
Anastomosis: neck
three hole
Worst outcomes occur in leaks from
chest rather neck
Majority of patients with esophageal ca present at stage
3
Layer essential in anastomotic repair
submucosa
Most common site of esophageal perforation during endoscopy
After repeated vomiting
Killian triangle
Distal thoracic esophagus
Order of preference of conduit for esophageal reconstruction
Stomach>colon>jejunum
45 y/o
progressive dysphagia to solid
first dx?
barium swallow
determines resectability of esophageal malignancy
freedom from distant metastases or distal nodal involvement, ability to resect adjacent involved structure
80 y/o
dysphagia with aspiration pneumonia
esophageal study contrast agent of choice?
Nonionic H20 soluble agent to minimize risk of pneumonitis
Benefits of lap Heller and partial fundoplication vs left thoracoscopic myotomy for achalasia
Dec length of stay
Dec post op reflux