LADA Flashcards
What does LADA stand for?
Latent autoimmune diabetes in adults
What is LADA?
A form of type 1 diabetes seen in adults
How can LADA progress?
Slowly over years or more rapidly to the need for insulin
What percentage of patients initially diagnosed with type 2 diabetes may have LADA?
Up to 30%
List the characteristics that differentiate LADA from type 2 diabetes.
- Lower BMI
- Lower triglycerides
- Higher HDL cholesterol
- Lower prevalence of hypertension
What is the age at onset criterion for diagnosing LADA?
At least 30 years
What must be positive for a diagnosis of LADA?
At least 1 autoantibody associated with type 1 diabetes
What is a subjective criterion for LADA diagnosis regarding insulin?
Not requiring insulin within the first 6 months after diagnosis
What are diagnostic clues for LADA?
- Symptomatic hyperglycemia
- Lack of response to metformin
- Family history of autoimmune disease
What confirms a diagnosis of LADA?
Presence of antibodies, particularly high levels of glutamic acid decarboxylase antibodies
What treatment is required for effective management of LADA?
Insulin
Have other interventions like sulfonylureas, SGLT-2 inhibitors, or GLP-1 receptor agonists been shown to be effective for LADA?
No
