ANTIDEPRESSANTS AND WT GAIN AND DM

Question 1

What is the effect of antidepressants on weight change?

Answer 1

Effect depends on medication and treatment duration

Short-term treatment (2-3 months) with SSRIs shows little or no weight change, while long-term treatment may lead to significant weight gain.

Question 2

What is the typical weight change associated with short-term SSRI use?

Answer 2

Little or no weight change

This is observed during the first 2-3 months of treatment.

Question 3

What is a potential reason for weight gain during long-term SSRI treatment?

Answer 3

Medication effects or recovery from depression

Recovery may reverse previous weight loss.

Question 4

Which antidepressant is typically associated with weight loss?

Answer 4

Bupropion

Bupropion is often used with naltrexone for weight loss.

Question 5

Which SSRI may be the least problematic in terms of weight gain?

Answer 5

Fluoxetine

Fluoxetine is noted for causing less weight gain compared to other SSRIs.

Question 6

Which SSRI is most problematic regarding weight gain?

Answer 6

Paroxetine

Paroxetine causes weight gain in 6% of patients, with an increase of 1.6%-3.6% of baseline weight.

Question 7

What is the weight change effect of Venlafaxine and Amitriptyline?

Answer 7

Generally weight neutral or promote weight loss

These medications do not significantly contribute to weight gain.

Question 8

What factors might contribute to weight gain during SSRI treatment?

Answer 8

• Depression remission
• Improved appetite
• Increased carbohydrate cravings
• Changes in serotonin 2C receptor activity

These factors may interact to influence weight changes.

Question 9

What may cause weight loss during initial SSRI treatment?

Answer 9

Poor appetite

This is often observed as a side effect during the early stages of treatment.

Question 10

What is the risk of diabetes associated with long-term SSRI use?

Answer 10

2-fold increased risk

Long-term use (more than 24 months) is linked to an incidence rate ratio of 2.06 for diabetes.

Question 11

What is the specific diabetes risk associated with Paroxetine?

Answer 11

Increased risk estimate of 1.33

This suggests Paroxetine may significantly contribute to the risk of developing diabetes.

Question 12

What demographic factors are unclear regarding weight changes during SSRI treatment?

Answer 12

Differences by age and sex

There is limited information on how these demographics affect weight changes.